Background: Hippocampal damages, which are accompanied by inflammation, are among the main causes of epilepsy acquisition. We previously reported that chronic intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) modulates epileptogenesis in rats. There is a network of gap junction channels in the hippocampus that contribute to epileptogenesis. Gap junction channels are formed ...

Background: Associated with sepsis is the illness known as acute kidney injury (AKI). AKI may be mediated by uric acid, and blood creatinine levels can utilized to diagnose condition measure function. Sambiloto (Andrographis paniculata) a traditional medicine that has flavonoid compounds reduce Xanthine Oxidase Inhibitors which acid levels.Objective: Septic model rats generated lipopolysacchari...

Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. The rats were divided into five groups (n=10 in each): (1) control (saline), (2) LPS (1 mg/kg, admin...

Lipopolysaccharide (LPS) is essential for most gram-negative bacteria and plays an important role in serum resistance, pathogenesis, drug protection from harsh environments. The outer core oligosaccharide of LPS involved bacterial recognition invasion host cells. D-galactosyltransferase WaaB responsible the addition D-galactose to LPS, which Salmonella typhimurium invasion. Here we report first...

Purpose: To investigate the therapeutic role of diosmetin in periodontitis and its probable mechanism action.Methods: Lipopolysaccharide (LPS) was used to induce periodontal cells. Cell viability apoptosis response LPS were evaluated using MTT TUNEL assays. The oxidative stress inflammatory responses LPS-induced effects cells detected enzyme-linked immunosorbent assay (ELISA). In addition, role...

Objective(s): Endometritis is the inflammation of the uterine lining that is associated with infertility. It affects milk production and reproductive performance and leads to huge economic losses in dairy cows. Dimethyl itaconate (DI), a promising chemical agent, has recently been proved to have multiple health-promoting effects. However, the effects of DI on endometri...

background and objectives: treatment of pseudomonas aeruginosa infections is greatly hampered by innate and acquired antibiotic resistance. the goal of this study was to compure the immunogenicity of conjugates of p. aeruginosa depolymerized alginate-diphtheria toxoid (d-algdt) and p. aeruginosa detoxified lipopolysaccharidediphtheria toxoid (d-lpsdt) in mouse model. materials and methods: algi...

background and objective: escherichia coli o157:h7, an emerging pathogen, causes severe enteritis and the extraintestinal complication of hemolytic-uremic syndrome. the goal of this study was to evaluate the conjugate of e. coli o157: h7 lipopolysaccharide (lps) with diphtheria toxoid (dt) as a candidate vaccine in mice model. material and methods: lps from e. coli o157:h7 was extracted by hot ...