Background: Accurate and early detection of non-alcoholic fatty liver, which is a major cause of chronic diseases is very important and is vital to prevent the complications associated with this disease. Ultrasound of the liver is the most common and widely performed method of diagnosing fatty liver. However, due to the low quality of ultrasound images, the need for an automatic and intelligent...

The liver is the main organ responsible for drug metabolism; hepatocyte-based culture models play a fundamental role in understanding physiology. While different types of two-dimensional and three-dimensional have been developed, failure to accurately mimic native liver, including extracellular matrix (ECM) composition, complex structure, rich vascular network as well shortage donors, impede th...

background: patients with bleeding disorders are frequently infected with hepatitis c virus (hcv). there are few reports on the effect of standard interferon in these patients and no published report on pegylated interferon. the aim of this study was to compare pegylated interferon alpha-2a and standard interferon alpha with ribavirin in patients with bleeding disorders and chronic hcv infectio...

hepatic inflammatory pseudotumor (ipt) is a rare non-neoplastic process of unknown etiology, generally following a benign inflammatory condition. it is often mistaken as an either primary or metastatic malignancy in imaging studies. we report a 48 year-old female with numerous target lesions (2-4 cm) seen on high resolution ultrasound, spiral ct scan, and mri in all liver lobes compatible with ...

despite the fact that hepatic involvement is frequently seen in systemic primary amyloidosis, major hepatic symptoms as primary manifestation and severe impaired liver function are rare. herein, we report a 38-year-old woman with primary hepatic amyloidosis, and severe  portal hypertension . the patient had ascites and markedly elevated alkaline phosphatase level at presentation. she had a rapi...

background: ritalin (methylphenidate methylphenidate) is an amphetamine used to treat adhd, symptoms of narcolepsy, and some people with depression. this study was to investigate the effect of ritalin food on blood albumin and some liver enzymes. materials and methods: in this study, 40 male wistar rats were randomized into 4 groups (1 control group, and three experimental groups). in the contr...

background: despite the prevalence of non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash), no treatment has been proven to be effective in these common diseases. although many studies have shown that lifestyle modifications such as increasing physical activities and exercise could be effective in the treatment of these common diseases, the optimal strategy is stil...

background there are several studies in the literature investigating factors which can induce non-alcoholic fatty liver disease (nafld) in different populations. however, the existing literature lacks powerful studies addressing the factors which may predict the severity of nafld. objectives in the current study, we aimed to evaluate factors independently associated with liver echogenicity in a...

background: nowadays, drug and observation are advised to patients with lymphocytic hypophysitis and in some cases with nonfunctioning pituitary macoadenoma, instead of surgery. case presentation: in this article, we report a woman with nonfunctional pituitary macroadenoma and panhypopitutarism and negative criteria for lymphocytic hypophysitis associated with increased liver enzymes. after thr...

introduction: cisplatin is an antineoplastic drug, which is widely used for the treatment of solid tumors. however, its clinical usage is limited because of its side effects such as hepatotoxicity. this study aimed to identify toxic effects of cisplatin on hepatocytes of rats. methods: a total of 45 adult sprague dawley rats weighing 200±30 g were randomly divided into experimental (n=30) and c...