Background: Non-alcoholic fatty liver disease (NAFLD) is increasingly a common disease which is created by the accumulation of fat in the liver. About 20% of adults and 5% of children suffer from this disease. In some studies, half of obese children had fatty liver disease and approximately 90% of the patients with fatty liver were obese. The aim of this study was to evaluate fatty liver diseas...

acetaminophen is an analgesic and antipyretic drug, which is widely used by public and poisoning with this drug, is common. one of the most important adverse effects of acetaminophen poisoning is centrilobullar necrosis in hepatic cells, which depends on activity of microsomal cytochrome p-450 (cyp) enzymes. the aim of this investigation was to find out the protective effect of nifedipine again...

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily that regulate the expression of genes involved in a variety of biological processes, including lipid metabolism and insulin sensitivity. Members of the PPAR family—in particular, PPAR—have more recently been shown to broadly regulate inflammatory and reparative responses. PPARis expressed...

Tumor hypoxia is a spatially and temporally heterogeneous phenomenon, which results from several tumor and host tissue-specific processes. To study the dynamics and spatial heterogeneity of hypoxia-inducible factor-1 (HIF-1)-specific transcriptional activity in tumors, we used repetitive noninvasive positron emission tomography (PET) imaging of hypoxia-induced HIF-1 transcriptional activity in ...

context cystic fibrosis (cf) is the most widespread autosomal recessive genetic disorder that limits life expectation amongst the caucasian population. as the median survival has increased related to early multidisciplinary intervention, other manifestations of cf have emergedespecially for the broad spectrum of hepatobiliary involvement. the present study reviews the existing literature on liv...

context celiac disease (cd) is defined as a permanent intolerance to ingested gluten. the intolerance to gluten results in immune-mediated damage of small intestine mucosa manifested by villous atrophy and crypt hyperplasia. these abnormalities resolve with initiationa gluten-free diet. evidence acquisition pubmed, ovid, and google were searched for full text articles published between 1963 and...

background a high proportion of patients suffering from end stage liver disease are from low socioeconomic classes , which limits their access to liver transplantation as the most effctive treatment of this condition because of cost barrier. objectives one of the most challenging aspects of liver transplantation is its affordability and utilization by those who need it the most. patients and me...

results: patients in the case and control groups were similar in age and admission vital signs. during the second operation, the bleeding volumes measured in the case and control groups were 66 ± 27.01 ml and 152 ± 85.4 ml, respectively. there was some pad-induced damage after the removal of the pad in the control group. patients and methods: twenty male patients with grade iv or v liver injuri...

background: dendritic cells (dcs) are potent antigen presenting cells for triggering of the immune reaction post transplantation. these cells are centrally involved in the initiation of t cell-dependent immune responses. objective: to compare the level of dc maturation and function in liver transplant recipients with healthy controls. methods: in this study, twelve peripheral blood samples were...