In this study we sought to determine the effect of sepsis on two sequelae of prolonged (24-h) beta-agonist administration, myocardial hypertrophy and catecholamine-induced cardiotoxicity. Sprague-Dawley rats were randomized to cecal ligation and perforation (CLP) or sham study groups and then further randomized to receive isoproterenol (2.4 mg. kg-1. day-1 iv) or placebo treatment. At 24 h, myo...

Current estimates suggest that about 25% of cancers are associated with chronic inflammation (Mantovani et al., 2008). Many cytokines and mediators of inflammation are known to have an important role in cancer pathogenesis, but the underlying mechanisms are still not fully understood. The high mobility group box 1 (HMGB1) protein was originally identified as a nuclear protein that can regulate ...

Ischemia-reperfusion injury is a pathogenic factor in the course of many clinical disorders, such as myocardial infarction, stroke, organ transplantation, burns, and circulatory shock. The extent of ischemia-reperfusion injury is dependent on the number of infiltrating leukocytes. With in vivo microscopy, we evaluated the effect of the recombinant form of soluble murine intercellular adhesion m...

AIm: This study aims to apply computed tomography perfusion imaging (CTPI) technology under in vivo conditions in order to explore its reliability and accuracy in evaluating the rat acute cerebral ischemia-reperfusion model (RACIRM). mAterIAl and methOds: The thread embolism method was used in 48 rats to create the RACIRM. Rats were divided into 2 groups as ischemia group and ischemia-reperfusi...

The present study investigates the effect of Withania somnifera (WS), a well-known adaptogenic agent in Indian system of Medicine, on acute cerebral reperfusion and long-term cerebral hypoperfusion in rats. Acute ischemiareperfusion (30 min occlusion of bilateral common carotid arteries followed by 45 min. reperfusion) and Long-term cerebral hypoperfusion (for 15 days) in C.F. strain rats were ...

Background: Metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) is a common public health problem. Visfatin is secreted by visceral adipose tissue and is an adipocytokine. It could be a pro-inflammatory adipocytokine and is related to the metabolic syndrome and non-alcoholic fatty liver disease. This study evaluated the association between visfatin levels in patients w...

Introduction: The present study was conducted with the aim of designing a liver phantom for dosimetry. To benchmark the results obtained by the developed liver phantom, another method was applied for the dosimetry of a real liver tissue using imaging. Materials and Methods: For the purpose of the study, a real liver tissue was converted into a phantom based on thegram-molecular weight of the co...

genesis of ischemia and reperfusion injury in the myocardium. Recent studies have suggested that a massive Ca influx may occur as a consequence of Na –Ca exchange via the sodium–calcium exchanger (NCX) during reperfusion which, in turn, may be caused by an accumulation of Na via the sodium–hydrogen exchanger (NHE) during ischemia. This results in an intracellular Ca overload, the detrimental ef...

This study was designed to define the effect of postischemic low Ca perfusion on recovery of high-energy phosphates, intraceUular pH, and contractile function in isolated rat hearts. Phosphorus-31 nuclear magnetic resonance spectroscopy was used to follow creatine phosphate, adenosine triphosphate, intraceUular inorganic phosphate, and intraceUular pH during control perfusion (15 minutes), tota...

Glycogen synthase kinase-3β (GSK3β) is a serine/threonine protein kinase that plays an important role in renal tubular injury and regeneration in acute kidney injury. However, its role in the development of renal fibrosis, often a long-term consequence of acute kidney injury, is unknown. Using amousemodel of renal fibrosis induced by ischemia-reperfusion injury, we demonstrate increased GSK3β e...