Introduction: It has been reported that traumas such as transverse abdominal incision before myocardial ischemia result in a significantly decreased infarct size. This phenomenon is named remote preconditioning of trauma. Since small skin burn is one of most common traumas, the effect of this injury on ischemia-induced arrhythmias and infarct size was investigated in a rat model of ischemia-rep...

Purpose: To study the effect of dexmedetomidine (Dex) on myocardial ischemia-reperfusion injury (MIRI), and associated mechanism action.Methods: Sixty Sprague-Dawley (SD) rats were assigned to sham, (I/R), Dex, MD groups (methyllycaconitine prior injection with Dex), 15 in each group. Pathological changes tissues determined all groups. Protein expression levels HMGB1, TLR4, NF-κB myeloid differ...

Background CMR is the imaging modality of choice to quantify myocardial injury in studies of cardioprotection. Remote ischemic conditioning (RIC), using transient limb ischemia and reperfusion, is a novel therapeutic intervention, which can protect the heart against acute ischemiareperfusion injury (IRI). Whether RIC can reduce myocardial infarct (MI) size, and improve myocardial salvage in ST-...

Introduction: It has been reported that traumas such as transverse abdominal incision before myocardial ischemia result in a significantly decreased infarct size. This phenomenon is named remote preconditioning of trauma. Since small skin burn is one of most common traumas, the effect of this injury on ischemia-induced arrhythmias and infarct size was investigated in a rat model of ischemia-...

Meldrum, Kirstan K., Daniel R. Meldrum, Xianzhong Meng, Lihua Ao, and Alden H. Harken. TNF-dependent bilateral renal injury is induced by unilateral renal ischemiareperfusion. Am J Physiol Heart Circ Physiol 282: H540–H546, 2002; 10.1152/ajpheart.00072.2001.—While tumor necrosis factor (TNF)is an important mediator of renal ischemiareperfusion (I/R) injury, its role in contralateral renal injur...

OBJECTIVES Recent studies have revealed that nitric oxide (NO) in concert with lipid peroxidation (LP) may play an important role in pathophysiological mechanism(s) of cerebral ischemia. In addition, hyperglycemia exaggerates the pathological changes during cerebral ischemia. The purpose of this study was to investigate the effects of vitamin E (VE) on LP, NO production, and superoxide dismutas...