IL-22 is currently a hot topic, with researchers generating approximately 400–500 related articles per year. However, articles by Xu et al. and Kulkarni et al. in this issue of JASN are the first to describe the involvement of IL-22 in the kidney.1,2 Interest in IL-22 is growing because of its unique range of cellular targets and the power of its effects,3,4 which are generating increasing exci...

chronic anemia is common in liver cirrhosis. in this setting the pathogenesis of anemia is complex and multifactorial. spur cell anemia is a serious disorder in cirrhotic patients associated with poor prognosis. liver transplantation constitutes the only therapeutic tool. we report a case of  a severe spur cell anemia in alcoholic liver cirrhosis. in the attempt to investigate the origin of the...

abstract        background and objectives: nonalcoholic fatty liver disease is the most common chronic liver disorder and is also currently considered as the hepatic manifestation of metabolic syndrome. regular exercise training may decrease fatty liver disease complications, although its impact is not yet clear. this study aimed to evaluate the effects of six weeks of aerobic training on liver...

introduction valproic acid (vpa, valproate) is an eight-branch fatty acid and varies from other antiepileptic drugs. vpa use might lead to mild to severe hepatotoxicity. the aim of this study was to investigate valproic acid impact on liver transaminases at the beginning of vpa treatment and after three and six months of it. materials and methods this study was designed as a cross sectional pro...

background: regarding to the growing prevalence of nonalcoholic fatty liver disease (nafld), concentrating on various strategies to its prevention and management seems necessary. the aim of this study was to determine the effects of symbiotic on c‑reactive protein (crp), liver enzymes, and ultrasound findings in patients with nafld. methods: eighty nafld patients were enrolled in this randomize...

epithelioid hemangioendothelioma (ehe) is a rare neoplasm of vascular origin which arises preferentially in soft tissue and bone, and rarely in the liver. its vascular nature is confirmed by positive staining for factor viii-related antigen and other endothelial cell markers (cd31, cd34) in addition to the pathologic characteristics of well-developed basal lamina, pinocytotic vesicles, and, mor...

objective: nonalcoholic fatty liver disease (nafld) is the most common form of liver disease in the world and it is one of the liver transplantation causes. the present study aimed to investigate the effect of purslane seeds on anthropometric parameters, fasting blood glucose (fbs), and liver enzymes in patients with nonalcoholic fatty livers. materials and methods: in this clinical trial, 54 p...

Redox balance maintaining is a prerequisite for normal cardiomyocytes metabolism. Reperfusion injury of the heart characterized by an explosive increase in ROS generation, cell membranes damage, dysfunction proteins, development muscle contracture etc. It was shown that hydrogen sulfide (H2S) and precursor its synthesis amino acid L-cysteine provided cardioprotective effect against ischemiarepe...