background: non-melanoma skin cancer is the most common malignant tumor in humans. the role of ultraviolet radiation is well-known in the pathogenesis of basal cell carcinoma (bcc) and squamous cell carcinoma (scc). cd10 is a zinc-dependent metallopeptidase known as common acute lymphoblastic leukemia antigen (calla). although cd10 expression has been investigated in some cutaneous tumors, to o...

Objective(s): Endometriosis is a complex gynecologic disease with unknown etiology. Noscapine has been introduced as a cancer cell suppressor. Endometriosis was considered as a cancer like disorder, The aim of present study was to investigate noscapine apoptotic effect on human endometriotic epithelial and stromal cells in vitro. Materials and Methods:In this in vitro study, endometrial biopsie...

human mesenchymal stem cells (hmscs), which also called mesenchymal stromal cells, are multipotent stem cell. human mscs typically are positive for the surface markers cd44, cd73, cd90, cd105, cd106, and also negative for hematopoietic markers cd34 and cd45.these cells can be isolated from postnatal bone marrow, adipose tissue, placenta, and scalp tissue, as well as from various fetal tissues. ...

The metastatic organotropism has been one of the cancer's greatest mysteries since the 'seed and soil' hypothesis. Although the role of EGFR in cancer cells is well studied, the effects of secreted EGFR transported by exosomes are less understood. Here we show that EGFR in exosomes secreted from gastric cancer cells can be delivered into the liver and is integrated on the plasma membrane of liv...

The liver is a specialized organ and plays an important role in our immune system. constitutes parenchymal cells which are hepatocytes cholangiocytes (60-80%) non-parenchymal cell like sinusoidal endothelial (LSECs), hepatic satellite/Ito cells, Kupffer neutrophils, mononuclear T B lymphocytes (conventional non-conventional), natural killer (NK) NKT cells. mounts rapid strong response, under un...

Nonalcoholic fatty liver disease (NAFLD) encompasses a range of manifestations, including steatosis and cirrhosis. Progressive disease is characterized by hepatic leukocyte accumulation in the form of steatohepatitis. The adhesion molecule vascular adhesion protein-1 (VAP-1) is a membrane-bound amine oxidase that promotes leukocyte recruitment to the liver, and the soluble form (sVAP-1) account...

Cancer immunotherapy is a relatively new and promising method of treating neoplasms. Understanding the antigen-directed cytotoxicity T-lymphocytes has become one central directions in involving immune system fight against cancer. Basic research this area led to invention checkpoint inhibitors, adoptive T-cell therapy, cancer vaccines. Cytokines can enhance action for their ability directly stim...

Nitric oxide (NO) signaling is important for the regulation of hematopoiesis. However, the role of individual NO synthase (NOS) isoforms is unclear. Our results indicate that the neuronal NOS isoform (nNOS) regulates hematopoiesis in vitro and in vivo. nNOS is expressed in adult bone marrow and fetal liver and is enriched in stromal cells. There is a strong correlation between expression of nNO...

background: mesenchymal stromal cells (mscs) are employed in various different clinical settings in order to modulate immune response. human autologous and allogeneic supplements including platelet derivatives such as platelet lysate (pl), platelet-released factors (prf) and serum are assessed in clinical studies to replace fetal bovine serum (fbs). the immunosuppressive activity and multi-pote...

objective(s):to study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. materials and methods:forty new zealand rabbits were randomly divided into five groups with eight rabbits in each group. for each group, bone defects were generated in the left humerus of four rabbits, and in the right humerus of the other four rabbits. to t...