A novel approach to hierarchical peptide-protein and protein-protein docking is described and evaluated. Modeling procedure starts from a reduced space representation of proteins and peptides. Polypeptide chains are represented by strings of alpha-carbon beads restricted to a fine-mesh cubic lattice. Side chains are represented by up to two centers of interactions, corresponding to beta-carbons...

The hierarchical hub covering facility location problems are applied to distribution systems, transportation, waste disposal, treatment services, emergency services and remote communication. The problems attempt to determine the location of service providers' facilities at different levels and specify their linking directions in order to reduce costs and to establish an appropriate condition in...

Cross docking is a logistics strategy that strives to reduce inventory holding costs, shipping costs, and delays in delivering the products. In this research, an optimization model is presented for split loading and unloading products by suppliers and customers, vehicle routing with fuzzy possibilistic time window constraints among them, assignment of vehicles to cross dock, consolidation and i...