human immunodeficiency virus infection / acquired immunodeficiency syndrome (hiv/aids) is a disease pertained to the human immune system. given its crucial role in viral replication, hiv-1 protease (hiv-1 pr) is a prime therapeutic target in aids therapy. in this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in hiv-1 pr in...

High-Throughput Docking has emerged as a well establish method for identifying lead components in the process of searching for new drugs. The High-Throughput Docking Service provides researchers with the ability to do drug screening using tools usually reserved for large research centers. The service provides web-based access to large clusters of computers and extensive searchable molecular lib...

This paper provides a comprehensive literature review of mathematical models in cross docking planning. From the reviews, the models are classified in three different levels regarding its decisions level which are operational, tactical, and strategic level. The researches in operational level are mainly related to develop model in scheduling, dock door assignment, transhipment problem, vehicle ...

The globalization of production and service enterprises increased the complexity of supply chain systems and processes. The complexity of supply problems leaded to the development of new shipment strategies. The optimal design of supply chain is an important success factor of the economical operation of enterprises. Within the frame of this paper the author compare the costs of the direct shipm...

Logistics sprawl is the phenomenon driving warehouses and freight terminals further away from city centers, for reasons that are mostly dependent on urban planning, field price economies of scale. In past, studies have already described logistics in Paris Metropolitan area. These concluded logistic facilities far center increased distance travelled, by extension, CO2 emissions. This study does ...

Background: Denileukin diftitox (trade name, Ontak) is the first recombinant immunotoxin (IM), in which the binding domain of diphtheria toxin has been replaced by the amino acid sequence of human interleukin-2 (DT389IL-2) using genetic engineering. Purity, stability, and structural property of the protein are critical factors for the scale-up production of this fusion protein. In this IM, loca...