in this paper, we consider a special case of weber location problem which we call goal location problem. the weber location problem asks to find location of a point in the plane such that the sum of weighted distances between this point and n existing points is minimized. in the goal location problem each existing point pi has a relevant radius ri and it’s ideal for us to locate a new facility o...

BACKGROUND The preferred method of treatment for atrial fibrillation (AF) is by catheter ablation, in which a catheter is guided into the left atrium through a transseptal puncture. However, the transseptal puncture constrains the catheter, thereby limiting its manoeuvrability and increasing the difficulty in reaching various locations in the left atrium. In this paper, we address the problem o...

OBJECTIVE Deep brain stimulation (DBS) surgeries commonly rely on brain atlases and microelectrode recordings (MER) to help identify the target location for electrode implantation. We present an automated method for optimally fitting a 3-dimensional brain atlas to intraoperative MER and predicting a target DBS electrode location in stereotactic coordinates for the patient. METHODS We retrospe...

Customer demand is dynamic and changeable; thus, optimality of the enterprise’s initial location cannot be guaranteed throughout planning period in order to minimize site selection cost maximize service reliability whole operation cycle. The enterprise divided into different stages, a static model established at fixed stage. In addition, multi-stage by introducing transfer between adjacent stag...