نتایج جستجو برای: locus coeruleus nucleus.

تعداد نتایج: 176904  

Journal: :physiology and pharmacology 0
nasrin haghighi dept. biology, shahid chamran university, ahwaz, iran. mahnaz kessmati hadi fathi moghadam2

introduction: oxytocin is a active neuropeptide of central nervous system. in this study the effects of naloxone (opioid receptor antagonist) and yohimbine (α-2 adrenergic receptor antagonist) on analgesic effect of oxytocin applied into the locus coeruleus (lc) nucleus were investigated. methods: adult male wistar rats were used. animals divided into different groups receiving saline, oxytocin...

Hojjatollah Alaii, Safoura Raufi,

Introduction: Opiates cause dependency via affect on central nervous system. Locus coeruleus nucleus is a main group of noradrenergic neurons in the brain that plays an important role in the expression of opioid withdrawal signs. During opioid withdrawal, brain waves change in addition to physical and behavioral signs. In this study, we examined the effects of locus coeruleus electrical sti...

Journal: :physiology and pharmacology 0
safoura raufi dept. physiology, isfahan university of medical science, isfahan, iran hojjatollah alaii

introduction: opiates cause dependency via affect on central nervous system. locus coeruleus nucleus is a main group of noradrenergic neurons in the brain that plays an important role in the expression of opioid withdrawal signs. during opioid withdrawal, brain waves change in addition to physical and behavioral signs. in this study, we examined the effects of locus coeruleus electrical stimula...

Journal: :Epilepsy & Behavior 2011
Tatiana Tocchini Felippotti Célio Marcos dos Reis Ferreira Renato Leonardo de Freitas Rithiele Cristina de Oliveira Ricardo de Oliveira Tatiana Paschoalin-Maurin Norberto Cysne Coimbra

The postictal state is generally followed by antinociception. It is known that connections between the dorsal raphe nucleus, the periaqueductal gray matter, and the locus coeruleus, an important noradrenergic brainstem nucleus, are involved in the descending control of ascending nociceptive pathways. The aim of the present study was to determine whether noradrenergic mechanisms in the locus coe...

2015
Gisela Patrícia Borges Juan Antonio Micó Fani Lourença Neto Esther Berrocoso

BACKGROUND The corticotropin-releasing factor is a stress-related neuropeptide that modulates locus coeruleus activity. As locus coeruleus has been involved in pain and stress-related patologies, we tested whether the pain-induced anxiety is a result of the corticotropin-releasing factor released in the locus coeruleus. METHODS Complete Freund's adjuvant-induced monoarthritis was used as infl...

Objective(s):The relationship between tramadol, as an antinociceptive drug, and locus coeruleus (LC), the main noradrenergic nucleus of the brain that affects regulation and modulation of pain through descending noradrenergic pathways was investigated. Materials and Methods: Male Sprague-Dawley rats were divided into four groups of 10 rats. The rats were fixed in stereotaxic instrument and then...

Journal: :iranian journal of basic medical sciences 0
mohammad ali mobasher 1 department of pharmaceutical biotechnology, faculty of pharmacy, shiraz university of medical sciences, shiraz, iran pharmaceutical sciences research center, shiraz university of medical sciences, shiraz, iran javad sajedianfard department of physiology, school of veterinary medicine, shiraz university, shiraz, iran akram jamshidzadeh pharmaceutical sciences research center, shiraz university of medical sciences, shiraz, iran naser naghdi department of physiology and pharmacology, institute pasture of iran, tehran, iran mohammad mehdi namvaran department of pharmaceutical biotechnology, faculty of pharmacy, shiraz university of medical sciences, shiraz, iran pharmaceutical sciences research center, shiraz university of medical sciences, shiraz, iran

objective(s):the relationship between tramadol, as an antinociceptive drug, and locus coeruleus (lc), the main noradrenergic nucleus of the brain that affects regulation and modulation of pain through descending noradrenergic pathways was investigated. materials and methods: male sprague-dawley rats were divided into four groups of 10 rats. the rats were fixed in stereotaxic instrument and then...

Journal: :Current Biology 2015
Lindsay A. Schwarz Liqun Luo

The release of the neurotransmitter norepinephrine throughout the mammalian brain is important for modulating attention, arousal, and cognition during many behaviors. Furthermore, disruption of norepinephrine-mediated signaling is strongly associated with several psychiatric and neurodegenerative disorders in humans, emphasizing the clinical importance of this system. Most of the norepinephrine...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1991
M A Romagnano R J Harshbarger R W Hamill

The present studies in the rat employed a combined retrograde transport-immunocytochemical technique to determine the origin in the brainstem of enkephalin (Enk) projections to spinal sympathetic nuclei, including the intermediolateralis nucleus, pars principalis (ILp). We found that Enk projections to the ILp nucleus are found in such serotonergic-containing areas as the raphe obscurus; raphe ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
G A Ordway C A Stockmeier G W Cason V Klimek

The norepinephrine transporter (NET) is a site of action for tricyclic antidepressant drugs and for drugs of abuse such as amphetamine and cocaine. In this study, the binding of [3H]nisoxetine to NETs in the noradrenergic cell group, the locus coeruleus, and the serotonergic cell groups, the dorsal raphe nuclei, was measured autoradiographically in postmortem human brain. [3H]nisoxetine binding...

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