The solubility data of Active Pharmaceutical Ingredients in organic solvents is an essential for pharmaceutical crystallization and drug formulation. In this work, two semi-empirical correlations- the Yaws model λ-h model- thermodynamic models – Wilson Model Non-random two-liquid are used to estimate lornoxicam ethanol water. parameters correlations coefficients calculated by optimizing average...

The aim of present investigation was to improve the solubility and dissolution rate limited absorption of lornoxicam (LXM) by making solid complexes using single and double hydrophilization approaches. For this, effect of Polyvinylpyrrolidone K-30 (PVP K-30) and Poloxamer-407 (PXM407) auxiliary substances on complexation of drug with β-cyclodextrin was studied by investigating their interaction...

Objective: To formulate economic transdermal patch of lornoxicam (LX) and to study its anti-inflammatory activity on acute and chronic inflammatory in rat models Method: Three LX transdermal patches (F1, F2 and F3) consist of Eudragit RL-100 and RS-100 in three different ratios (1:2, 1:1 and 2:1) were prepared respectively by the solvent evaporation technique. All formulations contain diethylph...

BACKGROUND Rheumatoid arthritis (RA) is a chronic inflammatory disease treated by nonsteroidal anti-inflammatory drugs (NSAIDs) including lornoxicam (LX). Nanocarriers have been used to increase the efficacy and reduce the side effects of various drugs. The objective of the present study was to compare the therapeutic efficacy of systemic administration of lornoxicam-loaded nanomicellar formula...

Nanoemulgels are considered as potential and ideal drug delivery systems for the transdermal administration of poorly soluble drugs like lornoxicam. Their intrinsic characteristics, such small globule size well excipient type, make passage easier. The current study was aimed at developing nanoemulgel based formulation lornoxicam coloaded with eucalyptol to enhance skin permeation bioavailabilit...