Simvastatin, a semisynthetic derivertive of lovastatin, is an important drug for the treatment of hypercholesteromia, and is traditionally prepared by direct alkylation of lovastatin. Chemical reaction conditons are very rigid, and the final product is difficult to purify, also the pressure of labor protection and environment protection is very high. Recently, with the devolpement in the resear...

Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the key enzyme that regulates cholesterol synthesis, lower serum cholesterol by increasing the activity of low density lipoprotein (LDL) receptors in the liver. In rat liver slices, the dose-response curves for inhibition of [14C]acetate incorporation into cholesterol were similar for the active acid forms of lovastatin, s...

The molecular and biochemical events underlying the onset of superficial scald in two pear cultivars with different susceptibility (‘Blanquilla’ ‘Conference’) was investigated fruit untreated treated lovastatin, 1-MCP or ethylene. ‘Conference’ pears were characterized by higher content flavonols linolenic acid (18:3), metabolites related to chilling injury resistance. In this cultivar, expressi...

Abstract. Rahmi Z, Yurnaliza Y, Hastuti LDS. 2022. Isolation and screening of lovastatin-producing endophytic fungi from lemongrass (Cymbopogon nardus L.). Biodiversitas 23: 4189-4194. Fungi have long been studied for their cholesterol-lowering compounds, known as statins the derivatives through fermentation in laboratory investigations. Therefore, this study aimed to isolate screen fungal stra...

The cAMP signal pathway controls various biological functions, including secondary metabolism of filamentous fungi. We found that exogenous cAMP represses the production of lovastatin, red pigments, and citrinin in Monascus. Interestingly, a mutant MK-1 with increased lovastatin and red pigments production was not influenced by cAMP on these productions, indicating that cAMP signaling might be ...

Statins were derived from Penicillium citrinium in 1976 by Endo and his colleagues. Brown et al7 showed that they act by inhibiting HMG-CoA reductase. The first studied statin was compactin which was renamed mevastatin. Lovastatin became the first statin to be approved for human use. Pravastatin and simvastatin are chemically modified derivatives of lovastatin. Atorvastatin, fluvastatin and cer...

Exposure of the human malignant peripheral nerve sheath tumor cell lines STS-26T, ST88-14, and NF90-8 to nanomolar concentrations of both lovastatin and farnesyl transferase inhibitor (FTI)-1 but not to either drug alone induced cell death. ST88-14 and NF90-8 cells underwent apoptosis, yet dying STS-26T cells did not. FTI-1 cotreatment induced a strong and sustained autophagic response as indic...

Lovastatin blocks the biosynthesis of the isoprenoid precursor, mevalonate. When Friend murine erythroleukemia (MEL) cells are cultured in medium containing lovastatin, the precursor of murine leukemia virus envelope glycoprotein (gPr90env) fails to undergo proteolytic processing, which normally occurs in the Golgi complex. Consequently, newly synthesized envelope proteins are not incorporated ...

Fourteen patients suffering from familial hypercholesterolemia (type IIa) participated in a double-blind, placebo-controlled trial that evaluated the effects of fish oil ethyl ester (K-85, 5.7 g/day) or a hydroxymethylglutaryl coenzyme A reductase inhibitor (lovastatin, 40 mg/day) alone or in combination on lipid metabolism and bleeding time at rest and after standardized exercise. Lovastatin t...