background: there is evidence that cd36 promotes foam cell formation through internalizing oxidized ldl (ox-ldl) into macrophages therefore, it plays a key role in pathogenesis of atherosclerosis. in addition, cd36 expression seems to be mediated by nuclear receptor peroxisome proliferator-activated receptor gamma (ppar-γ). the aim of the present study was to evaluate and compare the effect of ...

familial hypercholesterolemia (fh) is an autosomal co-dominant disorder of lipid metabolism, caused by mutations in ldl receptor gene. the penetrance of fh is almost 100%, meaning that half of the offspring of affected parents born with disease. the patients are at risk of premature coronary heart disease (chd). there is no report about the molecular basis of fh in iran. identification of mutat...

abstract probiotic products highly affect the health of consumers by reducing the risk of heart attacks and improving of desirable microflora in intestinal tract. in this study the effect of yogurt (500g/d for 3 wk) enriched with either bifidobacterium bifidum or lactobacillus acidophilus on the level of cholesterol, low density lipoprotein (ldl) and high density lipoprotein (hdl) of serum and ...

the non-enzymatic glycation of low density lipoprotein (ldl) is a naturally occurring chemical modification of apolipoprotein b as a result of condensation between lysine residues and glucose. glycated ldl is poorly recognized by ldl receptors and initiates different processes that can be considered proatherogenic. thus, ldl glycation may contribute in the increased atherosclerotic risk of pati...

background: oxidative modification of low-density lipoprotein (ldl) appears to be an early step in the pathogenesis of atherosclerosis. meanwhile, myeloperoxidase (mpo)-catalyzed reaction is one of the potent pathway for ldl oxidation in vivo. the aim of this study was to evaluate in vitro antioxidant effects of vitamins c and e on ldl oxidation mediated by mpo. methods: mpo was isolated from f...

probiotic products highly affect the health of consumers by reducing the risk of heart attacks and improving the desirable microflora in the intestinal tract. in this study the effect of yogurt (500g/d for 3 wk) enriched with either bifidobacterium bifidum or lactobacillus acidophilus on the level of cholesterol, low density lipoprotein (ldl) and high density lipoprotein (hdl) of serum and ...

background: a great deal of evidence has indicated that oxidatively modified ldl plays a critical role in the initiation and progression of atherosclerosis. antioxidants that can prevent ldl oxidation may act as antiatherogens. copper is a candidate for oxidizing ldl in atherosclerotic lesions. the binding of copper ions to ldl is usually thought to be a prerequisite for ldl oxidation by copper...

the non-enzymatic carbamylation of low density lipoprotein (ldl) is a naturally occurring chemical modification of apolipoprotein b as a result of condensation between lysine residues and cyanate derived from urea. carbamylated ldl is poorly recognized by ldl receptors and initiates different processes that can be considered proatherogenic. thus, ldl carbamylation may contribute to the increase...

the oxidative modification of low density lipoprotein (ldl) may play an important role in atherogenesis. antioxidants that can prevent ldl oxidation may act as antiatherogens. our understanding of the mechanism of ldl oxidation and factors that determine its susceptibility to oxidation is still incomplete. copper is a candidate for oxidizing ldl in atherosclerotic lesions. the binding of copper...

background: it is well established that oxidative modification of low density lipoprotein (ldl) plays a causal role in human atherogenesis and the risk of atherosclerosis is increased in patients with diabetes mellitus. we examined the in vitro effect of glucose on native and glycated ldl oxidation using copper ion dependent oxidation system. methods: in this study, ldl was isolated from plasma...