osteonecrosis (on) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. corticoid-induced on in rats and lipopolysaccharide (lps)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. d-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the ...

conclusions our successful extraction of purified lps from e. coli isolates of uti patients’ urine samples can be an important step to understand the uti disease conditions. results the silver-stained gel demonstrated both smooth and rough type lps by showing trail-like band patterns with the presence and lacking o-antigen region, respectively. coomassie blue staining showed no band assuring th...

Abstract Although propolis has been reported for having anti-inflammatory activities, its effects on complement system not much studied. This research was conducted to find out the of Indonesian expression levels C3, C1r/s, Bf, MBL, and C6 in zebrafish larvae which were induced by lipopolysaccharide (LPS). Counting macrophages migrating yolk sac liver histology carried out. Larvae divided into ...

background: myocardial dysfunction is one of the major complications in patients with sepsis where there is a relationship between the blood level of cytokines and the onset of myocardial depression. in many cases of sepsis, the presence of lipopolysaccharide (lps) has been established. lps binding protein (lbp) bound endotoxin is recognized by cd14/toll-like receptor-4 (tlr4) complexes in inna...

Inflammation caused by the excessive secretion of inflammatory mediators in abnormally activated macrophages promotes many diseases along with oxidative stress. Loganin, a major iridoid glycoside isolated from Cornus officinalis, has recently been reported to exhibit anti-inflammatory and antioxidant effects, whereas underlying mechanism not yet fully clarified. Therefore, aim present study is ...

Peroxiredoxin 1 (PRDX1) participates in tumor cell proliferation, apoptosis, migration, invasion, and the epithelial-to-mesenchymal transition (EMT). This study aimed to investigate effect of PRDX1 on EMT airway epithelial cells stimulated with lipopolysaccharide (LPS) transforming growth factor-beta (TGF-β1). overexpression significantly increased proliferation migration human bronchial (BEAS-...

The purpose of this study was to evaluate and characterize the pharmacological activity two orally administered IRAK4-inhibitors BAY 1834845 1830839 in healthy volunteers. Prednisolone placebo were used as active non-active controls, respectively. Skin inflammation induced by topical application Imiquimod (IMQ) cream for up 3 days. Before after IMQ challenge effect on erythema microperfusion as...

Cholesteatoma is a severe non-cancerous lesion of the middle ear characterized by massive inflammation, tissue destruction, and an abnormal growth keratinized squamous epithelium. We recently demonstrated presence pathogenic stem cells within cholesteatoma tissue, unfortunately their potential roles in regulating disease-specific chronic inflammation remain poorly understood. In presented study...