Sepsis is a life-threatening condition often leading to multiple organ failure for which currently no pharmacological treatment available. Endothelial cells (EC) are among the first respond pathogens and inflammatory mediators in sepsis might be sentinel target prevent occurrence of failure. Lipopolysaccharide (LPS) Gram-negative bacterial component that induces endothelial expression adhesion ...

The aim of the present study was to investigate effects diammonium glycyrrhizinate lipid ligand (DGLL) treatment on acute lung injury (ALI) and pulmonary edema induced by lipopolysaccharide (LPS) in Sprague?Dawley rats. Rats orally received 30, 60 120 mg/kg DGLL. After 1 h, rat ALI model established LPS (10 mg/kg) intraperitoneal injection. 6 evaluated using hematoxylin eosin staining technique...

Abstract Background Galacto-oligosaccharides (GOS) have been shown to modulate the intestinal microbiota of suckling piglets exert beneficial effects on function. However, modulation and function by GOS in inflammation injury models has rarely reported. In this study, we investigated colonic mucosal composition, barrier inflammatory response lipopolysaccharides (LPS)-challenged piglets. Methods...

Abstract Systemic lupus erythematosus (SLE) is an autoimmune condition characterized by the production of autoantibodies to cellular and nuclear self-antigens, with damage multiple organs. Immunization SLE autoantigen β2-glycoprotein I (β2GPI) TLR4 ligand lipopolysaccharide (LPS) induces a murine model generation antigens. LPS both inflammatory cytokines type interferons (IFNs) signaling throug...

Macrophage pyroptosis and related inflammatory responses play an important role in periodontitis. Kynurenic acid (KA) is hypothesized to have anti‑inflammatory potential, but whether KA can inhibit macrophage the underlying mechanisms remain unclear. Lipopolysaccharide (LPS) was used induce THP‑1‑derived macrophages. or ML385 pretreat macrophages, after which, cell viability, NOD‑like receptor ...

Abstract Decoy receptor 3 (DcR3), also known as tumor necrosis factor (TNFR) superfamily member 6b (TNFRSF6B), is a pleiotropic which modulates cell functions via decoy and non-decoy actions. DcR3 has been shown its anti-apoptotic anti-inflammatory effects on cancers inflammatory diseases. Toll-like receptors (TLRs), are the members of pattern recognition (PRRs), trigger response against invadi...

Purpose: To investigate the therapeutic role of diosmetin in periodontitis and its probable mechanism action.Methods: Lipopolysaccharide (LPS) was used to induce periodontal cells. Cell viability apoptosis response LPS were evaluated using MTT TUNEL assays. The oxidative stress inflammatory responses LPS-induced effects cells detected enzyme-linked immunosorbent assay (ELISA). In addition, role...