We prove that local projections (LPs) and Vector Autoregressions (VARs) estimate the same impulse responses. This nonparametric result only requires unrestricted lag structures. discuss several implications: (i) LP VAR estimators are not conceptually separate procedures; instead, they simply two dimension reduction techniques with common estimand but different finite?sample properties. (ii) VAR...

Sepsis is a systemic inflammatory response syndrome caused by various pathogenic microorganisms or toxins. Lung damage one of the causes death in patients with sepsis. This study aimed to investigate role miR-19a-3p and its regulation mechanism sepsis-induced lung injury. MH-S cells were treated lipopolysaccharide (LPS) establish injury cell model. C57BL/6 mice injected antagomiR LPS construct ...

Recent research revealed that dietary genistein supplementation for breeder hens can improve the immune function of offspring chicks. However, it remains unknown whether this maternal effect could intestinal health offspring. This study was conducted to explore mechanism involved in on mucosa and microbial homeostasis chicken A total 120 Qiling were fed a basal diet, 20 mg/kg genistein-suppleme...

Background and objectivesLasting LPS stimulation changes macrophages toward the M2 phenotype therefore resulting in immunodepression. Melatonin can improve sleep, adjust time difference, regulate immunity, anti-tumor. This study is to observe whether melatonin induce macrophage apoptosis reverse lasting LPS-induced immunodepression for lung cancer prevention explore possible mechanism.

Background: Sepsis is a common cardiovascular complication that can cause heart damage. The regulatory role of ubiquitin-specific peptidase 13 (USP13) on erythroid 2–related factor 2 (Nrf2) has been reported, but its in septic cardiomyopathy remains unclear.Methods: Sprague Dawley (SD) rat model myocardial injury was constructed by lipopolysaccharides (LPS). serum lactate dehydrogenase (LDH) an...

Abstract Selenomethionine (SeMet) is a widely used food supplement. However, the research on effect of SeMet intestinal immune function not enough. Therefore, in this experiment, was added to diet chickens, and lipopolysaccharide (LPS) as harmful stimulation study chickens. We chose chicken jejunum object. The results showed that LPS treatment decreased expressions selenoproteins induced inflam...

Septicaemia caused by gram-negative pathogens is a dangerous infection which is associated with high incidence of liver dysfunction. The severe and acute hepatotoxicity is presumably due to massive release of endotoxin into systemic circulation after bacterial killing. The direct toxic effect of endotoxin is probably due to the increased production of reactive oxygen intermediates as O 2 - , p...

Background: Neutrophils are the most abundant white blood cells in humans. Recently, a novel strategy called the formation neutrophil extracellular traps (NETs) was described. NETs is a new strategy for pathogen response. This study focused on whether LPS induced NETs release in vitro in the HL60 cell line. Methods: In this study, the HL60 cell line was used for culture and DMSO for induction ...

Background : Propylene glycol (1,2-propanediol, PG) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. While PG is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. Objective: To evaluate the effect of PG in sepsis induced by the bacterial endotoxin lipopolysaccharide (LP...

Preconditioning (PC) as a protective strategy against noxious insults can decline cell death and apoptosis. It has been approved that mitochondria play a key role in PC mechanism. The critical role of complex I (CI) in oxidative phosphorylation machinery and intracellular ROS production, particularly in the brain, accentuates its possible role in PC-induced neuroprotection. Here, differentiated...