Objective(s): Longan seeds have been used as a folk medicine in China. Longan seed extract (LSE) is known for antioxidative, antiproliferative, hypoglycemic, and hypouremic effects. However, its anti-inflammatory effect has not been shown. Materials and Methods: In this study, Sprague-Dawley (SD) rats were given LSE orally (vehicle, 10, and 30 mg/kg) for 3 days to its test anti-inflammatory eff...

Objective(s): In the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (EGCG) on lipopolysaccharide (LPS)-induced hepatotoxicity by using Hep3B human hepatoma cells. Specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of LPS-associated cytotoxicity. Consequently, the hepatocellu...

Objective(s):Lipopolysaccharide (LPS)-induced endotoxemia is known to cause male infertility. This study was designed to explore the effects of bacterial LPS on histomorphometric changes of mice testicular tissues.    Materials and Methods: In experiment 1, a pilot dose responsive study was performed with mice that were divided into five groups, receiving 36000, 18000, 9000, and 6750 µg/kg body...

the aim of this study was to examine the anti-inflammatory effects of co-administration of growthhormone-releasing peptide-2 (ghrp-2) and growth hormone (gh) on tumor necrosis factor-α (tnf-α),interleukin-6 (il-6) and inducible nitric oxide synthase (inos) gene expression induced by lps in the mousebrain. thirty-five male nmri mice (25±5 g) were injected through the mouse tail vein with saline,...

objective(s): in the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (egcg) on lipopolysaccharide (lps)-induced hepatotoxicity by using hep3b human hepatoma cells. specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of lps-associated cytotoxicity. consequently, the hepatocellu...

Objective(s): Abnormal lung cell death including autophagy and apoptosis is the central feature in acute lung injury (ALI). To identify the cellular mechanisms and the chronology by which different types of lung cell death are activated during lipopolysaccharide (LPS)-induced ALI, we decided to evaluate autophagy (by LC3-II and autophagosome) and apoptosis (by caspase-3) at different time point...

Objective(s): Recent studies revealed that microRNAs (miRNAs) may play crucial roles in the responses and pathologic processes of spinal cord injury (SCI). This study aimed to investigate the effect and the molecular basis of miR-103 on LPS-induced injuries in PC12 cells in vitro and SCI rats in vivo. Materials and Methods: PC12 cells were exposed to LPS to induce cell injuries to mimic the in ...

BackgroundLeiomyosarcoma (LMS) and liposarcoma (LPS) are ultra-rare sarcomas in pediatric (0-18 years) young adult (19-30) populations. We aimed to analyze their clinical characteristics at these ages determine whether they should be considered with the same therapeutic strategy both populations.MethodsNational retrospective multicenter study of all patients (0-30 included sarcoma database “Con...