We investigated the effect of high-frequency stimulation of the basolateral amygdala (BLA) on the induction of long-term potentiation (LTP) in the medial perforant path (PP)-dentate gyrus (DG) synapses of anesthetized rats. A conditioning stimulation (100 pulses at 100 Hz) of the ipsilateral BLA did not change the DG synaptic potential. However, when the BLA conditioning stimulation was applied...

We have addressed the expression of long-term potentiation (LTP) in hippocampal CA1 by comparing AMPA and NMDA receptor-(AMPAR- and NMDAR-) mediated postsynaptic signals. We find that potentiation of NMDAR-mediated signals accompanies LTP of AMPAR-mediated signals, and is associated with a change in variability implying an increase in quantal content. Further, tetanic LTP of NMDAR-mediated sign...

The mossy fiber-CA3 synapse displays an N-methyl-D-aspartate-receptor-independent mu-opioid-receptor-dependent form of long-term potentiation (LTP) that is thought not to display cooperativity or associativity with coactive afferents. However, because mossy fiber LTP requires repetitive synaptic activity for its induction, we reevaluated cooperativity and associativity at this synapse by using ...

The optogenetic method allows us to manipulate cellular activity with high spatiotemporal resolution. most widely used tool is channelrhodopsin-2 that can be utilized control neuronal at the level. However, tools capable of inducing synaptic plasticity level single synapses (spines) have been lacking. We recently developed a photoactivatable CaMKII by fusing light-sensitive domain, LOV2, CaMKII...

AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) unsilencing is an often proposed expression mechanism both for developmental long-term potentiation (LTP), involved in circuitry refinement during brain development, and for mature LTP, involved in learning and memory. In the hippocampal CA3-CA1 connection naïve (nonstimulated) synapses are AMPA signaling and AMPA-silent synapses a...

The late, transcription- and translation-dependent phase of long-term synaptic potentiation (L-LTP) at the Schaffer collateral synapse of the hippocampus is an experimental model of the synaptic plasticity underlying long-lasting memory formation. L-LTP is typically induced by homosynaptic tetanic stimulation; but associative forms of learning are likely to require the heterosynaptic pairing of...

Long-term potentiation (LTP) of inhibitory synaptic transmission in rat visual cortex was investigated using intracellular recording in slice preparations. The inhibitory postsynaptic potential (IPSP) of layer V cells evoked monosynaptically by layer IV stimulation was recorded while excitatory postsynaptic potentials (EPSPs) were blocked by adding NMDA and non-NMDA receptor antagonists to the ...

Klann, Eric. Cell-permeable scavengers of superoxide prevent shown that extracellular application of superoxide dismulong-term potentiation in hippocampal area CA1. J. Neurophysiol. tase (SOD) and catalase, enzymes that catalyze the re80: 452–457, 1998. Long-term potentiation (LTP) in hippocampal moval of superoxide and hydrogen peroxide, respectively, area CA1 is generally dependent on N-methy...

the effect of cysteamine, a somatostatin depletor, on synaptic plasticity induced by tetanic and paired-pulse stimulation was investigated in rat hippocampal ca1. for this purpose, hippocampal slices from saline (1 ml/kg, s.c.) and cysteamine (200 fig/kg, s.c.)-treated and intact rats were used. population spikes were recorded following schaffer collateral stimulation. to induce ltp, primed bur...

The roles of both kainate receptors (KARs) and metabotropic glutamate receptors (mGluRs) in mossy fiber long-term potentiation (MF-LTP) have been extensively studied in hippocampal brain slices, but the findings are controversial. In this study, we have addressed the roles of both mGluRs and KARs in MF-LTP in anesthetized rats. We found that MF-LTP could be induced in the presence of either Glu...