than 10 percent of the cases. With increasing practice our yield in the diagnosis of localized lung disease is now well over 90 percent. This is a safe simple procedure which can be accomplished in any hospital where image-intensification fluoroscopy and good cytologic services are available. In summary, we feel that the preferred method for obtaining tissue from undiagnosed localized lung lesi...

Use of circulating tumour DNA (ctDNA) as a liquid biopsy has been proposed for potential identification and monitoring of solid tumours. We investigate a next-generation sequencing approach for mutation detection in ctDNA in two related studies using a targeted panel. The first study was retrospective, using blood samples taken from melanoma patients at diverse timepoints before or after treatm...