Initiation of allergic airway pathology often depends on the protease activity inhaled allergen. Previous studies have shown that IL-17–driven neutrophil and eosinophil responses can promote pathology1Kim J. Chang Y. Bae B. Sohn K.H. Cho S.H. Chung D.H. et al.Innate immune crosstalk in asthmatic airways: innate lymphoid cells coordinate polarization lung macrophages.J Allergy Clin Immunol. 2019...

Abstract Vaccines against SARS-CoV-2 are urgently required, but early development of vaccines SARS-CoV-1 resulted in enhanced disease after vaccination. Careful assessment this phenomena is warranted for vaccine SARS CoV-2. Here we report detailed immune profiling ChAdOx1 nCoV-19 (AZD1222) and subsequent high dose challenge two animal models mediated disease. We demonstrate rhesus macaques the ...