Background: The aim of the study was to evaluate radiographic features systemic sclerosis-associated interstitial lung disease. Patients and methods: 116 patients with disease (SSc-ILD) from 2010 2019 comprised our retrospective study. All were subject high resolution computed tomography (HRCT). ILD patterns classified into 7 as IIPs analyzed pathology. We chose two staging method semi-quantita...

RSV is the most significant cause of serious lower respiratory tract infection in infants and young children worldwide. There is currently no vaccine for the virus, and antiviral therapy (e.g., ribavirin) has shown no efficacy against the disease. We reported that alternatively activated macrophages (AAMs) mediate resolution of RSV-induced pathology. AAM differentiation requires macrophage-deri...

Coxsackievirus B (CVB) is a significant pathogen of neonatal diseases with severe systemic involvement and high mortality. Hence, it is essential to develop a CVB-induced acute systemic disease model on newborn mouse and study the injury at the onset phase. In this work, a clinical strain of CVB3, Nancy, and its variant strain, Macocy, were adopted in 24 hour old neonates by oral infection. The...

Despite the availability of vaccines, influenza is a considerable public health problem, which emphasizes the need for development of additional strategies to enhance host defense against influenza. Wolfberry, or goji berry, long used as a medicinal food in China, has recently been shown to improve immune response in mice. Because immune response plays a key role in the body's defense against p...

Fibrosis Michael J. Segel, Pazit Y. Cohen, Gabriel Izbicki, Reuven Or 2, Thomas G. Christensen3, Shulamit B. Wallach-Dayan, Raphael Breuer (1) Lung Cellular & Molecular Biology Laboratory−Institute of Pulmonology and (2) Bone Marrow Transplantation Department Hadassah University Hospital and Hebrew University-Hadassah Medical School Jerusalem, Israel and (3) Mallory Institute of Pathology, Depa...

We report a case of bilateral apical lung bullae that collapsed following an episode of community-acquired pneumonia with bilateral air fluid levels. With standard treatment for community-acquired pneumonia, management of a patient that may have qualified for bullectomy, (as in our case) showed complete resolution of all pathology without surgical intervention. Conservative management took prec...

Davood Mansouri , Narges Mikaniki1, Monireh Kamali1, Ayyub Ghafoorian1, Majid Marjani1 , Zohreh Mohammad Taheri 4,5 1 Department of Internal Medicine ,Division of Infectious Disease and Clinical Immunology, 2 Mycobacteriology Research Center, 3 Lung Transplantation Research Center, 4 Department of Pathology, Molecular Pathology Section, 5 Tracheal Disease Research Center, NRITLD, Shahid Behesht...