In contrast to the human lutropin receptor (hLHR), very few naturally occurring activating mutations of the structurally related human follitropin receptor (hFSHR) have been identified. The present study was undertaken to determine if one aspect underlying this discrepancy might be a general resistance of the hFSHR to mutation-induced constitutive activity. Five different mutations were introdu...

Potent luteinizing hormone-releasing hormone analogues are known to cause regression of hormone-dependent mammary tumors. We have observed that high and long-lasting serum levels of a potent luteinizing hormone-releasing hormone analogue [desglycyl10-(D-leucyl6) luteinizing hormone-releasing hormone ethylamide, leuprolide] resulted from vaginal administration which effectively caused down regul...

im of the study: Rasayan drugs act inside the human body by modulating the neuro-endocrino-immune system. Vaajikaran rasayan is the special ategory of rasayan which investigate the reproductive system and enhance sexual function. Curculigo orchioides, Astercantha longifolia and ucuna pruriens are well known vajikaran rasayan herbs. The effect on sexual behaviour and reproductive parameters are ...

We describe a simplified method for purifying radiolabeled glycopeptide hormones (thyrotropin, lutropin, follitropin, and human choriogonadotropin), which results in preparations of over 95% immunoreactivity. This method is based on competitive elution from columns of the plant lectin, concanavalin A, and is applicable to glycopeptide hormones derived from several species.

Luteinizing-hormone-stimulated testosterone biosynthesis was inhibited by cycloheximide during incubation of rat testis intersitial tissue in vitro and also by puromycin and cycloheximide during incubation of Leydig-cell preparations, but not by chloramphenicol. These results suggest that a protein regualtor(s) formed by cytoplasmic protein synthesis is involved in steroidogenesis in the rat te...

Physiol, 214(2): 213-217. 1968.-The possibility of a circadian pattern of luteinizing hormone (LH) synthesis and release was investigated by measuring LH in pituitary and plasma samples collected at 4-hr intervals over a 24-hr period from ovariectomized rats. Some of the rats had been pretreated with PMSG or HCG before prepuberal ovariectomy; other rats which were not injected were ovariectomiz...