The TRAP (thyroid hormone receptor associated proteins)/Mediator complex serves as a transcriptional coactivator. In Drosophila, Kohtalo (Kto) and Skuld (Skd), homologs of TRAP subunits, TRAP230 and TRAP240, respectively, are necessary for eye development. However, the transcriptional activators that require Kto and Skd have not been identified. Here we provide evidence that Kto and Skd are ess...

The difference in threshold sensitivities that are found when examining the visual field (VF) with static versus kinetic perimetric methods is called stato-kinetic dissociation (SKD). In this pilot study, we describe a semi-automated procedure for quantifying SKD. Fifteen patients with VF defects were examined with kinetic and static perimetry. SKD values were defined as positive when the stati...

OBJECTIVE Approximately 10% to 15% of Kawasaki disease (KD) is refractory to treatment with initial intravenous immunoglobulin (IVIG). However, there is no consensus on pharmacologic treatment of refractory KD (rKD). Demographic characteristics of patients with rKD and regional variability in their treatment in the United States have not been reported on a large scale. The goal of this study wa...

Artificial transcription factors (ATFs) and genomic nucleases based on a DNA binding platform consisting of multiple zinc finger domains are currently being developed for clinical applications. However, no genome-wide investigations into their binding specificity have been performed. We have created six-finger ATFs to target two different 18 nt regions of the human SOX2 promoter; each ATF is co...

1Associate Professor and Head,Department of EEE, SKD College of Engineering, Gooty, AP, India 2PG Student, SKD College of Engineering, Gooty, AP, India 3Principal, SKD College of Engineering, Gooty, AP, India ------------------------------------------------------------------------------***------------------------------------------------------------------------------Abstract The objective of thi...

The need always exists for indexing mechanisms that can precisely retrieve imagery from a database, as well as maintain certain efficiencies for large-scale image database search. To achieve this, we developed a hybrid search tree called SKD-Metric tree. This novel approach merges the classification power of the statistical k-dimensional tree and the efficiency of computation of the Metric-tree...

BACKGROUND To assess differences between four different voxel-based dosimetry methods (VBDM) for tumor, liver, and lung absorbed doses following (90)Y microsphere selective internal radiation therapy (SIRT) based on (90)Y bremsstrahlung SPECT/CT, a secondary objective was to estimate the sensitivity of liver and lung absorbed doses due to differences in organ segmentation near the liver-lung in...

1,3 Associate Professor and Head, Department of EEE, SKD College of Engineering, Gooty, AP, India 2,4 PG Student, SKD College of Engineering, Gooty, AP, India --------------------------------------------------------------------------------***------------------------------------------------------------------------------Abstract: In this paper, a method based on the PortHamiltonian (PH) system an...

In this paper, we propose Stochastic Knowledge Distillation (SKD) to obtain compact BERT-style language model dubbed SKDBERT. each distillation iteration, SKD samples a teacher from pre-defined team, which consists of multiple models with multi-level capacities, transfer knowledge into student in an one-to-one manner. Sampling distribution plays important role SKD. We heuristically present thre...

The malarial parasite Plasmodium must complete a complex lifecycle in its Anopheles mosquito host, the main vector for Plasmodium. The mosquito resists infection with the human malarial parasite P. falciparum by engaging the NF-κB immune signaling pathway, IMD. Here we show that the conserved transcriptional mediators Kto and Skd are involved in the regulation of the mosquito IMD pathway. RNAi-...