In this letter, we investigate the mutual information rate (MIR) achieved by an independent identically distributed (IID) Gaussian input on intensity-driven signal transduction channel. Specifically, asymptotic expression of continuous-time MIR is given. Next, aiming at low computational complexity, also deduce approximately numerical solution for MIR. Moreover, corresponding lower and upper bo...

Dieser Beitrag präsentiert ein webbasiertes Serious Game, das Studierenden in medizinischen Studiengängen die Möglichkeit gibt, Arzt-PatientenGespräche in Form von Rollenspielen mit simulierten Patienten selbständig und systematisch zu trainieren. Der Phase der Immersion (Rollenspiel) folgt dabei eine Phase der distanzierten Reflexion, um den lernförderlichen Perspektivenwechsel zu unterstützen...

In this paper we develop an asymptotic theory for estimation based on signed ranks in the ARMA model when the innovation density is symmetrical. We provide two classes of estimators and we establish their asymptotic normality with the help of the asymptotic properties for serial signed rank statistics. Finally, we compare our procedure to the one of least-squares, and we illustrate the performa...

b a c k g r o u n d & aim: multi-state models can help better understand the process of chronic diseases such as cancers.  these models  are influenced  by assumptions  like individual  homogeneity.  this study aimed to investigate the effect of lack of individual homogeneity  assumption  in multi-state models. methods & materials: to investigate the effect of lack of individual homogeneity ass...

objective(s):micrornas (mirnas) are small non-coding rna molecules that regulate gene expression. they have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (ckd). in the present study, we elucidated the role of micror...

Objective(s): MicroRNAs (miRs) are a class of small non-coding RNAs which are associated with tumor growth and progression. In the present study, we assessed the expression of selected miRs in malignant, benign, and adjacent normal breast tissues. Materials and Methods: The expression of miR-1297, miR-3191-5P, miR-4435, and miR-4465 were...

In this study, at the first stage, the rupture criterion of bubbles wall in Aluminum metal foam liquid was investigated by using Lattice Boltzmann. The two phases modeling were accomplished by using a modified Shan-Chen model. This model was run for several bubbles in A356+3wt.%SiC melt system. Then, bubbles morphologies (virtual metallographic) for A356+3wt.%SiC foams were simulated. Results s...

Two-sample tests for multivariate and especially for non-Euclidean data are not fully explored. This paper presents a novel test based on a similarity graph constructed on the pooled observations from the two samples. It can be applied to multivariate data and non-Euclidean data as long as a dissimilarity measure on the sample space can be defined, which can usually be provided by domain expert...

abstract        background and objective: various cellular factors affect the process of hiv activity. one of these cellular factors are structures known as microrn that are expected to be involved in controlling hiv replication and infectivity. the expression of one or a set of them may represent the patient's clinical conditions. in this study,  the expression of mir-29a and mir-29b invo...

the statistical analysis of spatial data is usually done under gaussian assumption for the underlying random field model. when this assumption is not satisfied, block bootstrap methods can be used to analyze spatial data. one of the crucial problems in this setting is specifying the block sizes. in this paper, we present asymptotic optimal block size for separate block bootstrap to estimate the...