Liquid-crystalline macrocyclic compounds, tethered by two or three azobenzenes bearing alkoxy side chains, exhibit isothermal phase transitions from liquid-crystal to isotropic as well as from crystal to isotropic phases upon light irradiation due to the drastic conformational change of their macrocyclic backbone.

Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical molecules. So far, a large number of macrocyclic natural products have been isolated and synthesized. The construction of macrocycles is generally considered as a crucial and challenging step in the synthesis of macrocyclic natural products. Over the last several decades, numerous efforts have been underta...

The random non-standard peptide integrated discovery (RaPID) system has proven to be a powerful approach to discover de novo natural product-like macrocyclic peptides that inhibit protein functions. We have recently reported three macrocyclic peptides that bind to Pyrococcus furiosus multidrug and toxic compound extrusion (PfMATE) transporter and inhibit the transport function. Moreover, these ...

Macrocyclic complexes and their chemistry is a growing area of research in inorganic and bioinorganic chemistry in point of its biological significance [1]. Macrocyclic complexes have also received special attention because of their mixed soft –hard donor acceptor character and versatile coordination behavior and their pharmacological properties [2]. Macrocyclic ligands and complexes have versa...

In an effort to examine the interaction between dioxygen and iron-macrocyclic complexes, and to understand how this interaction was affected by those different macrocyclic ligands, dioxygen binding with iron-porphyrin, iron-phthalocyanine, iron-dibenzotetraaza[14]annulene, and iron-salen complexes is investigated by means of quantum chemical calculations utilizing Density Functional Theory (DFT...

A series of macrocyclic imides and Schiff-bases have been prepared via the cyclocondensation of pyridine-2,6-dicarbonyl dichloride (1) with L-ornithine methyl ester to give the corresponding macrocyclic bisester 2. Treatment of 2 with hydrazine hydrate gave macrocyclic bisacid hydrazide 3, which was used as starting material. Condensation of bishydrazide 3 with diacid anhydrides or aromatic ald...

magnetic resonance imaging (mri) contrast agents most commonly agents used in diagnosing different diseases. several agents have been ever introduced with different peculiar characteristics. they vary in potency, adverse reaction and other specification, so it is important to select the proper agent in different situations. we conducted a systematic literature search in medline/pubmed, web of s...

The title compound, C(28)H(52)N(6) (6+)·6Cl(-)·4H(2)O, is a dinucleating 28-membered centrosymmetric hexa-azamacrocyclic complex. The macrocyclic ligand adopts a chair-like conformation, with the crystallographic inversion center located in the macrocyclic cavity. The six chloride ions and four water mol-ecules are situated symmetrically outside the macrocyclic cavity. The crystal structure is ...

Macrocyclic complexes of Mn, Co, Ni and Cu using a macrocyclic ligand derived by the condensation of Trimethoprim and diethyl phthalate have been prepared and characterized by electronic, IR and NMR spectral studies as well as magnetic moment and conductivity. On the basis of spectral studies, an octahedral geometry has been proposed for all the complexes. INTRODUCTION: The chemistry of macrocy...

Macrocyclic peptides are a promising class of compounds that can often engage challenging therapeutic targets. Display technologies, such as mRNA display, allow for the efficient discovery macrocyclic peptides. This article reviews current approaches generating peptide libraries using display and highlights some recent examples ribosomal incorporation nonproteinogenic amino acids into