Structurally diverse libraries of novel small molecules represent important sources of biologically active agents. In this paper we report the development of a diversity-oriented synthesis strategy for the generation of diverse small molecules based around a common macrocyclic peptidomimetic framework, containing structural motifs present in many naturally occurring bioactive compounds. Macrocy...

The macrocyclic lactones are the biggest selling and arguably most effective anthelmintics currently available. They are good substrates for the P-glycoproteins, which might explain their selective toxicity for parasites over their vertebrate hosts. Changes in the expression of these pumps have been implicated in resistance to the macrocyclic lactones, but it is clear that they exert their anth...

The synthesis and photophysical properties of butadiyne-linked chlorophyll and porphyrin dimers in toluene solution and in several self-assembled prismatic structures are described. The butadiyne linkage between the 20-positions of the macrocycles results in new electronic transitions polarized along the long axes of the dimers. These transitions greatly increase the ability of these dimers to ...

Determination of the clinical importance of gadolinium (Gd) deposition must include the entire body. The benefit/risk assessment of only cerebral Gd deposition is not sufficient. The conclusion from the study of Schlemm et al., ‘Dentate nucleus T1 hyperintensity is not associated with gadobutrol’, suggests the authors’ confidence in administration of the macrocyclic agent gadobutrol. The statem...

A macrocyclic aromatic pyridone pentamer was shown to catalyze highly efficient transition-metal-free arylations of unactivated aromatic C-H bonds with aryl iodides and bromides in the presence of potassium tert-butoxide.

An unprecedented macrocyclic luminescent octanuclear cluster cyclo-[{Pt(C6Cl5)2(mu-OH)(mu-Ag)}4] (Pt-Ag) 2 was self-assembled by the formation of Pt(II)-Ag(I) bonds; the optical properties of this complex were also investigated.

The anion binding affinity of a macrocyclic Rh complex can be allosterically regulated by reaction with a small molecule (an isocyanide), which effects a change in macrocycle size and shape.

In a bulk membrane transport experiment, a dynamic combinatorial library (DCL) has been used to transport calcium ions; the calcium ions amplify the formation of a macrocyclic carrier which results in transport.

o-Phthalonitrile couples with chelating dioxime on nickel(II), with formation of a dinuclear nickel(II) macrocyclic complex--the first representative of a new class of imine-appended macrocycles.