macrocyclic heterobinuclear zn(ii)–cu(ii) complexes with phenol based dicompartmental ligands possessing contiguous hexa- and penta-coordination sites were prepared by a stepwise procedure. the ligands include similar n4o2 and dissimilar n(imine)3o2 and n(amine)3o2 coordination sites sharing two phenolic oxygen atoms. the six-coordination site comprises two pyridyl pendant arms on the amine nit...

Inhibition of histone deacetylase (HDAC) function is a validated therapeutic strategy for cancer treatment. Of the several structurally distinct small molecule histone deacetylase inhibitors (HDACi) reported, macrocyclic depsipeptides possess the most complex cap groups and have demonstrated excellent HDAC inhibition potency and isoform selectivity. Unfortunately, the development of macrocyclic...

This research explores the first design and synthesis of macrocyclic peptide aldehydes as potent inhibitors of the 20S proteasome. Two novel macrocyclic peptide aldehydes based on the ring-size of the macrocyclic natural product TMC-95 were prepared and evaluated as inhibitors of the 20S proteasome. Both compounds inhibited in the low nanomolar range and proved to be selective for the proteasom...

A series of 18-membered macrocyclic complexes of metal Ni(II) of the type [M(H2Cy )] have been synthesized and characterized on the basis of spectral, magnetic and conductivity studies. The macrocyclic ligands H 4 Cy1-4 (Fig. 1) are tetrabasic having four imido hydrogen but behave in a dibasic manner. Out of eight nitrogens, four imido and four imino, ligands utilize four imido nitrogens for sq...

the macrocyclic ligands 2,3,5,6-bis{3’-bromo-5’-tert-butyl benzo-5-phenyl benzo} 12c3 (l1), 2,3,5,6-bis{3’-bromo-5’-tert butyl-benzo-5’-phenyl-benzo}15c4 (l2), 2,3,5,6-bis{3’-bromo-5’-tert butyl-benzo-5’-phenyl-benzo}18c5 (l3) have been synthesized and their alkaline metal compounds with naclo4∙h2o and kclo4  have been prepared. chemical formulas of all compounds have been characterized by usin...

The increase of the ionic strength amplifies the species bearing acidic side chains from a bio-inspired dynamic combinatorial library of macrocyclic pseudopeptides, in close resemblance to the evolution observed for the proteins of halophilic microorganisms.

A practical and modular approach to obtain a diverse set of 14-membered macrocyclic compounds from carbohydrates is developed that utilizes functional groups at C-1 and C-5. The evaluation of this toolbox in various zebrafish assays led to the identification of 2.7f as an antiangiogenesis agent.

The title compound, C(12)H(16)N(12), is a centrosymmetric mol-ecule which comprises of a hexa-aza[14]annulene macrocyclic ring fused with two pyrazole rings. The macrocyclic ring is essentially planar, with an r.m.s. deviation of 0.0381 Å. The electron pairs of the amino groups are delocalized with the conjugated system of the macrocycle. Strong intra-molecular N-H⋯N hydrogen bonds arranged in ...

The field of heteropolymetallic complexes is of current interest in connection with the structures and roles of polymetallic active sites in biological systems [1], and the design of new molecular materials with magnetic, optical and electrical properties [2,3]. Among various relevant systems, oxamido-bridged polynuclear complexes [2,4] and phenolato-oxygen-bridged macrocyclic complexes [5,6] r...

The crystal structure of the title compound, [Ni(C8H20N4)(C12H8N2)](ClO4)2, has been determined by X-ray diffraction. The Ni(II) ion is six coordinated with four nitrogen atoms of the tetradentate macrocyclic ligand and two nitrogen atoms of the bidentate ligand in a distorted octahedron geometry. The folded tetradentate macrocyclic ligand adopts a configuration having four five-membered chelat...