نتایج جستجو برای: macrophage

تعداد نتایج: 53700  

Journal: :Blood 1995
T Tanigawa N Nicola G A McArthur A Strasser C G Begley

The physiologic program of macrophage differentiation normally proceeds in a coordinated manner in response to several different growth factors. Although the utilization of common receptor subunits may explain in part overlapping biologic functions, mechanisms by which unique actions are mediated remain obscure. We examined growth factor-induced macrophage differentiation in M1 leukemia cells t...

Journal: :Arteriosclerosis, Thrombosis, and Vascular Biology 2021

Objective: Macrophage-mediated inflammatory response is closely associated with the neovascularization process following hindlimb ischemia. We previously demonstrated that HO-1 (heme oxygenase-1) in macrophages evoked proinflammatory reactions and tissue damage. Here, we evaluated role played by macrophage-derived elucidated its underlying molecular mechanisms perfusion recovery after Approach ...

Journal: :Frontiers in Immunology 2023

Background and objectives The relationship between the tumor microenvironment network of key signaling pathways in cancer plays a role occurrence development tumors. Tumor-associated macrophages (TAMs) are important inflammatory cells play an tumorigenesis progression. Macrophages malignant tumors, mainly M2 subtype, promote progression by producing cytokines down-regulating anti-inflammatory i...

Journal: :Journal of atherosclerosis and thrombosis 2000
T Biwa M Sakai M Shichiri S Horiuchi

We and other groups have recently demonstrated that oxidized low density lipoprotein (Ox-LDL) induces proliferation of macrophages in vitro. Since previous immunohistochemical studies demonstrated that macrophages and macrophage derived foam cells proliferated in situ in atherosclerotic lesions, it seems reasonable to expect that the Ox-LDL-induced macrophage proliferation might be linked to th...

2016
Jian Ji Dingming Shu Mingzhu Zheng Jie Wang Chenglong Luo Yan Wang Fuyou Guo Xian Zou Xiaohui Lv Ying Li Tianfei Liu Hao Qu

Metabolites from intestinal microbes modulate the mucosal immune system by regulating the polarization and expansion of T cells. Whether the microbial metabolites influence macrophage polarization, however, is poorly understood. Here, we show that the large bowel microbial fermentation product, butyrate, facilitates M2 macrophage polarization, in vitro and in vivo. The supernatant from butyrate...

2015
Geming Lu Ruihua Zhang Shuo Geng Liang Peng Padmini Jayaraman Chun Chen Feifong Xu Jianjun Yang Qin Li Hao Zheng Kimberly Shen Juan Wang Xiyu Liu Weidong Wang Zihan Zheng Chen-Feng Qi Chuanping Si John Cijiang He Kebin Liu Sergio A Lira Andrew G Sikora Liwu Li Huabao Xiong

Here we show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2 macrophages. eNOS and nNOS mutant mice show comparable M1 macrophage polarization compared with wild-type control mice. Addition of N6-(1-iminoethyl)-L-lysine dihydrochloride, an iNOS inhibitor, significantly enhances M1 macrophage polarizat...

Journal: :Medical research archives 2023

Macrophage is the immune phagocytic cell, playing variety of immunological and inflammatory reactions. The macrophage activation has been extensively studied in vitro using culture media like Dulbecco's modified Eagle’s medium (DMEM) Ham's F-12 (F-12) response to bacterial infection, tumor development, cytokines so on. In study during co-culture with EL-4 cells, we found different phenotypes J7...

2016
Liang Peng Hui Zhang Yuanyuan Hao Feihong Xu Jianjun Yang Ruihua Zhang Geming Lu Zihan Zheng Miao Cui Chen-Feng Qi Chun Chen Juan Wang Yuan Hu Di Wang Susan Pierce Liwu Li Huabao Xiong

The regulation of macrophage orientation pathological conditions is important but still incompletely understood. Here, we show that IL-10 and Rag1 double knockout mice spontaneously develop colitis with dominant M1 macrophage phenotype, suggesting that IL-10 regulates macrophage orientation in inflammation. We demonstrate that IL-10 stimulation induced miR-146b expression, and that the expressi...

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