BACKGROUND Sustained and dysfunctional macrophage activation promotes inflammatory cardiometabolic disorders, but the role of long intergenic noncoding RNA (lincRNA) in human macrophage activation and cardiometabolic disorders is poorly defined. Through transcriptomics, bioinformatics, and selective functional studies, we sought to elucidate the lincRNA landscape of human macrophages. METHODS...

Inflammation drives atherosclerotic plaque progression and rupture, and is a compelling therapeutic target. Consequently, attenuating inflammation by reducing local macrophage accumulation is an appealing approach. This can potentially be accomplished by either blocking blood monocyte recruitment to the plaque or increasing macrophage apoptosis and emigration. Because macrophage proliferation w...

Staphylococcus aureus is a member of the human commensal microflora that exists, apparently benignly, at multiple sites on host. However, as an opportunist pathogen it can also cause range serious diseases. This requires ability to circumvent innate immune system establish infection. Professional phagocytes, primarily macrophages and neutrophils, are key cells which interact with S. , acting ga...