background: evidence indicates that neuropathic pain pathogenesis is not confined to changes in the activity of neuronal systems but involves interactions between neurons, inflammatory immune and immune-like glial cells. substances released from immune cells during inflammation play an important role in development and maintenance of neuropathic pain. it has been found that minocycline suppress...

The use of nanoparticles for intracellular drug delivery could reduce the toxicity and side effects but, uptake these nanocarriers induce adverse on cells tissues after their incorporation. Macrophages play a central role in host defense are responsible vivo nanoparticle trafficking. Assessment capacity against pathogenic micro-organisms uptake, is necessary to prevent infections associated wit...

Transcription of early growth response gene-1 (Egr-1) is required for macrophage differentiation. Since granulocyte-macrophage colony-stimulating factor (GM-CSF) induces macrophage proliferation as well as the transcription of Egr-1 mRNA, we characterized the induction of Egr-1 protein in murine peritoneal macrophages following treatment with GM-CSF. As determined by Western blot analysis, the ...

Immunotherapy has been used for years in many types of cancer therapy. Recently, cancer immunotherapy has focused on mechanisms which can enhance the development of cell-mediated immunity. Anticancer medications are administered to inhibit immunosuppressive factors such as nagalase enzyme, which is produced by neoplastic cells and destroys macrophage activating factor (Gc-MAF). Anti-neoplastics...