نتایج جستجو برای: macrophage

تعداد نتایج: 53700  

2011
Susan ZY Lo James H Steer David A Joyce

INTRODUCTION Methotrexate (MTX) induces macrophage apoptosis in vitro, but there is not much evidence for increased synovial macrophage apoptosis in MTX-treated patients. Macrophage apoptosis is reported, however, during clinical response to anti-tumor necrosis factor-alpha (TNF-α) treatments. This implies that TNF-α promotes macrophage survival and suggests that TNF-α may protect against MTX-i...

Journal: :Diabetes 2008
Evren Caglayan Bradley Stauber Alan R. Collins Christopher J. Lyon Fen Yin Joey Liu Stephan Rosenkranz Erland Erdmann Leif E. Peterson Robert S. Ross Rajendra K. Tangirala Willa A. Hsueh

OBJECTIVE Cardiac fibrosis is an important component of diabetic cardiomyopathy. Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands repress proinflammatory gene expression, including that of osteopontin, a known contributor to the development of myocardial fibrosis. We thus investigated the hypothesis that PPARgamma ligands could attenuate cardiac fibrosis. RESEARCH DESIGN A...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2010
Theresa W Gauthier Xiao-Du Ping Levan Gabelaia Lou Ann S Brown

We have previously demonstrated that fetal ethanol exposure deranges the function and viability of the neonatal alveolar macrophage. Although altered differentiation of the alveolar macrophage contributes to pulmonary disease states within the adult lung, the effects of fetal ethanol exposure on the normal differentiation of interstitial to alveolar macrophage in the newborn lung are unknown. I...

2016
Bangwei Luo Jinsong Wang Zongwei Liu Zigang Shen Rongchen Shi Yu-Qi Liu Yu Liu Man Jiang Yuzhang Wu Zhiren Zhang

Inflammation resolution is an active process, the failure of which causes uncontrolled inflammation which underlies many chronic diseases. Therefore, endogenous pathways that regulate inflammation resolution are fundamental and of wide interest. Here, we demonstrate that phagocyte respiratory burst-induced hypoxia activates macrophage erythropoietin signalling to promote acute inflammation reso...

2016
Wing Yin Cheng HoangDinh Huynh Peiwen Chen Samuel Peña-Llopis Yihong Wan

Tumor-associated macrophage (TAM) significantly contributes to cancer progression. Human cancer is enhanced by PPARγ loss-of-function mutations, but inhibited by PPARγ agonists such as TZD diabetes drugs including rosiglitazone. However, it remains enigmatic whether and how macrophage contributes to PPARγ tumor-suppressive functions. Here we report that macrophage PPARγ deletion in mice not onl...

Journal: :Journal of leukocyte biology 2016
Maria Barberà-Cremades Alberto Baroja-Mazo Pablo Pelegrín

Macrophages represent a highly heterogenic cell population of the innate immune system, with important roles in the initiation and resolution of the inflammatory response. Purinergic signaling regulates both M1 and M2 macrophage function at different levels by controlling the secretion of cytokines, phagocytosis, and the production of reactive oxygen species. We found that extracellular nucleot...

Journal: :The Journal of Experimental Medicine 1983
M J Banda E J Clark Z Werb

Mouse macrophage elastase, a metalloproteinase secreted by inflammatory macrophages, catalyzed the limited proteolysis of selected subclasses of mouse immunoglobulins, including monomeric IgG2a, IgG3, and some forms of IgG2b. Mouse IgG1 was resistant to elastase degradation; however, human IgG1 was degraded. IgG3 in immune complexes was cleaved in a manner similar to that of monomeric IgG3. Deg...

Journal: :Journal of lipid research 2009
Tracie Seimon Ira Tabas

Macrophage apoptosis is an important feature of atherosclerotic plaque development. Research directed at understanding the functional consequences of macrophage death in atherosclerosis has revealed opposing roles for apoptosis in atherosclerotic plaque progression. In early lesions, macrophage apoptosis limits lesion cellularity and suppresses plaque progression. In advanced lesions, macrophag...

Journal: :The Journal of clinical investigation 1987
M J Banda E J Clark S Sinha J Travis

Native and oxidized alpha 1-proteinase inhibitor (alpha 1-PI) were compared as substrates for the metalloproteinase macrophage elastase. At substrate concentrations at which native alpha 1-PI was readily degraded by macrophage elastase, oxidized alpha 1-PI was hardly degraded at all. Incubation of macrophage elastase with oxidized alpha 1-PI before the addition of native alpha 1-PI showed that ...

2014
Shweta Joshi Alok R. Singh Muamera Zulcic Lei Bao Karen Messer Trey Ideker Janusz Dutkowski Donald L. Durden

Although it is well-established that the macrophage M1 to M2 transition plays a role in tumor progression, the molecular basis for this process remains incompletely understood. Herein, we demonstrate that the small GTPase, Rac2 controls macrophage M1 to M2 differentiation and the metastatic phenotype in vivo. Using a genetic approach, combined with syngeneic and orthotopic tumor models we demon...

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