Background and Aims: Nitric oxide (NO) has an essential role in inflammation and has been related to pathogenesis and the progress of numerous inflammatory-based diseases, including some cancers. Peganum harmala (P. harmala) is a medicinal plant used for the treatment of numerous diseases such as several infections. Also, anti-inflammatory effects of P. harmala extracts and its derivatives (har...

This study aimed to evaluate the antileishmanial efficacy of oxaliplatin against Leishmania major both in-vitro and in-vivo. The IC50, CC50, and SI of oxaliplatin against promastigotes, murine macrophages, Raw 264.7 cells, and intramacrophage amastigotes of L. major were investigated in-vitro. The effects of this drug on intrace...

Cells of innate immunity, mainly monocytes/macrophages, form a long-term nonspecific immunological memory during the initial encounter with pathogen, so-called trained immunity. Mevalonate pathway metabolites play an important role in formation The aim this investigation was to study effect modulators mevalonate pathway, and zoledronate, on immunity human animal monocytes/ macrophages. Material...

Human stanniocalcin-1 (STC1) is a paracrine factor associated with inflammation and carcinogenesis. The role of STC1 in the pro- anti-inflammatory functions differentiating macrophage, however, not clear. In this study, our data showed that phorbol 12-myristate 13-acetate (PMA) treatment induced human leukemia monocytic cells (ThP-1) differentiation to M0 macrophages. was accompanied by signifi...

Objective: We previously reported smooth muscle cells (SMCs) represent ?50% of foam in human coronary and ?70% apoE (apolipoprotein E)-deficient mouse aortic atheromas exhibit reduced expression the cholesterol exporter ABCA1 (ATP-binding cassette transporter A1). A major stimulus for is flux out lysosomes, generated by hydrolysis lipoprotein cholesteryl esters LAL (lysosomal acid lipase). In t...

Squaric acid dibutylester (SADBE) is a topical sensitizer useful for contact immunotherapy of alopecia areata (AA). However, the mechanism action not fully understood. Macrophages activated by cytokines such as IL-1β or IL-4 are reported to promote hair growth. M2 macrophages induced IL-4, IL-10 IL-13 exhibit anti-inflammatory function and produce several growth factors that induce tissue repai...

The virulence of gram-positive bacterium Listeria monocytogenes depends on its capacity to infect non-professional phagocytes and proliferate inside them. Listerias captured by mononuclear phagocytic cells during the infectious process are resistant lysosomal digestion can macrophages. Internalin B (InlB), one key pathogenicity factors L. monocytogenes, interacts with mammalian receptors c-Met ...

Background & Objective: There is a complicated interaction between leishmaniasis and the host immune cells, and also between the host immune cells. These interactions have fundamental effects on the outcome of the disease. The current study aimed at characterizing the number, distribution, co-localization, and interrelation of 4 types of inflamma...

Abstract Macrophages are unique cells of the innate immunity and can be found in various tissues (tissue resident macrophages; TRMs). TRMs play a pivotal role tissue homeostasis contribute to onset progression certain diseases. We others have developed macrophage-based cellular immunotherapies explored field immune cell farming using induced pluripotent stem (iPSCs). Combination iPSCs bioreacto...