Magnesium ions are essential for the maintenance of the functional and structural integ· rity of the myocardium. Experimental magnesium deficiency induces cardiac necrosis and enhances susceptibility to cardiotoxic agents; magnesium administration is protective. Recent investigations indicate that cellular loss of magnesium may be a basic biochemical mechanism in the evolution of myocardial les...

BACKGROUND Previous studies have evaluated the impact of oral magnesium on blood pressure; however, they used magnesium salts with low bioavailability, had methodological issues, and showed differing results. OBJECTIVE To evaluate the long-term blood pressure-lowering ability of oral magnesium L-lactate versus placebo in patients with implanted cardioverter defibrillators (ICDs). METHODS In...

The temporal relationship between the systemic and myocardial concentrations of magnesium and some of its acute cardiovascular effects were examined after short i.v. infusion administration of magnesium (30 mmol over 2 min) in five awake chronically instrumented sheep. Magnesium decreased mean arterial blood pressure and systemic vascular resistance (SVR) by 23 and 41% from baseline, respective...

Previous observations on the effect of oral magnesium and peptone on thrombin generation time are examined. The smallest amounts of magnesium and peptone regularly producing a significant shift demonstrable after one hour are 0.25 g. magnesium and 15 g. peptone. The oral effect can be reproduced by the intravenous injection of magnesium. The minimum amount required is 50 mg. The effect is trans...

A large-scale survey of the normal magnesium content of various human tissues was carried out to facilitate clinical detection of magnesium deficiency, especially occult deficiency.A review of the literature favours the magnesium content of skeletal muscle as the most reliable index of the body's store of magnesium. There is a significant difference (P < 0.001) in both the serum and erythrocyte...

Magnesium deficiency and hypomagnesemia remain quite prevalent, particularly in patients in intensive care units, and may have important clinical consequences. Magnesium should be measured directly in clinical circumstances in which a risk for magnesium deficiency exists and appropriately corrected when found. This commentary reviews the current knowledge of magnesium homeostasis and the risk f...

1. A low urinary magnesium was induced in normal volunteer subjects by giving cellulose phosphate; magnesium was added in vitro to yield urine samples of normal and high magnesium concentrations. 2. After rapid evaporation of these urine samples at pH 5.3 to standard osmolality the calcium oxalate crystals were measured by microscopy and isotopic methods. 3. There was a clear inverse correlatio...

Magnesium is a chemical element with the atomic number 12, an atomic weight of 24, and the common oxidation number 12. Magnesium is an alkaline metal and the eighth most abundant element in the Earth’s crust, where it constitutes about 2% by mass, and ninth in the Universe. Magnesium is easily built up in supernova stars by the sequential addition of three helium nuclei to carbon. Magnesium ion...

BACKGROUND Magnesium is an antagonist of (N-methyl D-Aspartate) NMDA receptor and its related canals, and may affect perceived pain. OBJECTIVES The aim of this study was to evaluate the impact of intravenous magnesium on the hemodynamic parameters, analgesic consumption and ileus. PATIENTS AND METHODS A randomized, double blind, placebo controlled study was performed. Thirty two patients of...

BACKGROUND The findings of prospective cohort studies are inconsistent regarding the association between dietary magnesium intake and serum magnesium concentration and the risk of hypertension. We aimed to review the evidence from prospective cohort studies and perform a dose-response meta-analysis to investigate the relationship between dietary magnesium intake and serum magnesium concentratio...