The principle of magnetic drug targeting, wherein therapy is attached to magnetically responsive carriers and magnetic fields are used to direct that therapy to disease locations, has been around for nearly two decades. Yet our ability to safely and effectively direct therapy to where it needs to go, for instance to deep tissue targets, remains limited. To date, magnetic targeting methods have ...

The specific delivery of chemotherapeutic agents to their desired targets with a minimum of systemic side effects is an important, ongoing challenge of chemotherapy. One approach, developed in the past to address this problem, is the i.v. injection of magnetic particles [ferrofluids (FFs)] bound to anticancer agents that are then concentrated in the desired area (e.g., the tumor) by an external...

magnetic nanoparticles attracted a great deal of attention in the medical applications due to their unique properties. the most exceptional property of magnetic particles is their response to a magnetic force, and this property has been utilized in applications such as drug targeting, bioseparation, contrast agents in magnetic resonance imaging (mri) and heating mediators for cancer therapy. in...

Investigations of magnetic micro- and nanoparticles for targeted drug delivery began over 30 years ago. Since that time, major progress has been made in particle design and synthesis techniques, however, very few clinical trials have taken place. Here we review advances in magnetic nanoparticle design, in vitro and animal experiments with magnetic nanoparticle-based drug and gene delivery, and ...

Magnetic modulated drug delivery system addresses the major problem of initial biodistribution of drug carrier. It involves the use of particulate carriers to a localized diseased site. Magnetic microspheres can be used for sitespecific drug targeting as in case of tumors, magnetic bioseparation and also can be used for non-targeted drug delivery as in case of contrast agents (MRI) and drug res...

BACKGROUND Superparamagnetic nanoparticles are currently used as contrast agents for magnetic resonance imaging. These particles can also be used as drug carriers for local chemotherapy, called magnetic drug targeting. Using an external magnetic field, colloidal nanoparticles can be directed to a specific body compartment (i.e. tumor). MATERIALS AND METHODS After magnetic drug targeting in an...

Magnetic nanoparticles attracted a great deal of attention in the medical applications due to their unique properties. The most exceptional property of magnetic particles is their response to a magnetic force, and this property has been utilized in applications such as drug targeting, bioseparation, contrast agents in magnetic resonance imaging (MRI) and heating mediators for cancer therapy. In...

several species of magnetotactic bacteria have been discovered recently. these bacteria synthesize intracellular magnetic nanoparticles in specific sizes and shapes and arrange them in chains. these particles called magnetosomes and can be used for drug-delivery, cell-targeting and hyperthermia. magnetotactic bacteria navigate along the magnetic field; this process is known as ‘magnetotaxis’ wh...

magnetic nanoparticles can bind to different drug delivery systems and can be used for drug targeting to a specific organ by using an external magnetic field as well as used in hyperthermia by heating in alternating magnetic fields. the characteristics of iron oxide nanoparticles are significantly affected by particle size, shape and zeta potential, among which the particle size plays the most ...