Background A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic approach to the management of various cardiopulmonary disorders associated with endothelial dysfunction. Novel sGC stimulators, including riociguat (BAY 63-2521), have a dual mode of action: they sensitize sGC to endogenously produced nitric oxide (NO) and also directly stimulate sGC in...

We report a rare case of prostatic carcinoma associated with cystic degeneration. Cystic masses within the prostate are known. Benign cystic masses are more common and include congenital cysts of mullerian duct or mesonephric duct origin. Acquired cysts can be either retention cysts, parasitic or malignant in nature. Cysts accompanying prostatic carcinoma are moreover rare. The acute retention ...

Electrophysiological studies have been performed on 62 subjects with malignant lymphoma and the results compared with those of 35 control subjects matched for age. There was evidence of impairment of conduction consistent with a generalized peripheral neuropathy in 22 subjects (35%). Histological and electronmicroscopic studies were performed on sural nerve biopsy material from five subjects, a...

Excision of large and giant melanocytic nevi presents a distinct challenge to the pediatric plastic surgeon. The exact risk of malignant degeneration remains unknown. These unsightly lesions can be psychologically damaging to both parent and child. The pediatric plastic surgeon must have an armamentarium of techniques for reconstructing the various body areas and must always balance aesthetic a...

non-alcoholic steatohepatitis is a form of chronic hepatitis. fatty degeneration may involve liver focally or as a whole. the patient was a 41-year-old woman who was diabetic and admitted in buali hospital in ghazvin because of right flank pain, fever, vomiting and diarrhea. the patient was treated as pyelonephriris. liver function tests were as below: alt: 62 (40) ast: 54 (40), alkaline phosoh...

background: giant retroperitoneal uterine leiomyomas are uncommon. degenerative changes of a leiomyoma may lead to unusual presentation resulting in misdiagnosis preoperatively. the final diagnosis can be made either intraoperatively or histologically. case: we report a 45-year-old multiparous women presented with abdominal distension and fatigue for six months. abdominopelvic sonography and co...

Here, we report the case of a patient with a slowly-progressing anterior mediastinal teratoma submitted to surgical resection. The anatomopathological examination of the sample revealed malignant degeneration to carcinoid tumor. Such evolution is very rare, and we have found only three related studies in the literature. We describe the clinicopathological features of the tumor and discuss the t...

Linear porokeratosis is a genodermatosis, caused by a clonal proliferation of keratinocytes along the lines of Blaschko. This type of porokeratosis is particularly susceptible to malignant degeneration e.g. to Bowen disease, a squamous cell carcinoma (SCC) in situ with the potential for significant lateral spread. Here we report a case of linear porokeratosis on the left leg of a 56-year-old ma...

Benign cystic ovarian teratoma is the most common ovarian neoplasm accounting for 10–25 % of ovarian tumors. Complications of cystic teratomas include torsion (16 %), malignant degeneration (2 %), infection (1 %), and rupture (1 %). It can rupture into the bladder, small bowel, rectum, sigmoid colon, vagina, abdominal wall, and peritoneal cavity. We report a case of ovarian dermoid perforating ...