Abstract Malignant cutaneous melanoma is one of the most common cancers in young adults. During last decade, targeted and immunotherapies have significantly increased overall survival patients with malignant melanoma. Nevertheless, disease progression common, a lack predictive biomarkers patient response to therapy hinders individualized treatment strategies. To address this issue, we performed...

PURPOSE Cutaneous melanoma is a common, aggressive cancer with increasing incidence. The identification of melanoma-specific deregulated genes could provide molecular markers for lymph node staging assays and further insight into melanoma tumorigenesis. EXPERIMENTAL DESIGN Total RNA isolated from 45 primary melanoma, 18 benign skin nevi, and 7 normal skin tissue specimens were analyzed on an ...

Malignant melanoma caused by malignant transformation of melanocytes is associated with high mortality and difficult to manage. Metastasis not uncommon (up 31% all cases) closely a poor prognosis. Although rare (4–5%), extracutaneous has been reported; however, primary the sacrum extremely (only three case reports date). Here, we present 51-year-old patient who underwent surgical treatment for ...

Malignant melanoma is known for its wide range of histologic patterns and its ability to mimic other malignant tumors. Malignant melanoma is generated in the skin and sinus paranasalis by a malignant tumor of melanocytic origin. Malignant melanoma is usually quickly diagnosed by the presence of melanin granules. On the other hand, amelanotic melanoma is without melanin granules and is often dif...

Melanoma is the most malignant cutaneous tumor. The incidence of melanoma accounts for the sixth place among malignant diseases, 5% of malignancies among men and 4% of malignancies among women; it stands for 1.4% of deaths caused by malignant disease (Fisher et al., 2008). The incidence of malignant melanoma has constantly been increasing and it has reached 3% per year in the last several years...

BACKGROUND To study whether use of β-blockers increases survival in patients with malignant melanoma because experimental data suggest that catecholamine hormones may be involved in stimulating the aggressiveness of malignant melanoma. METHODS A total of 4,179 patients diagnosed with malignant melanoma in Denmark with a median follow-up of 4.9 years and identified in the Danish Cancer Registr...

Patients with malignant melanoma are at an increased risk of developing subsequent primary melanomas and also nonmelanoma cutaneous cancers. Several studies have reported an association between malignant melanoma and breast cancer, bladder cancer, colorectal cancer, neuroectodermal tumours, non-Hodgkin's lymphoma, leukaemia and renal cell carcinoma. We report a case series of patients with a di...

Oral malignant melanoma is a rare aggressive neoplasm of middle age, has predilection for the palate and maxillary gingiva or alveolar ridge and about 1/3rd of these neoplasms may develop from existing melanosis. A case of malignant melanoma in a 55 year old male is being reported. The patient was treated surgically. It is emphasised that the presence of pigmented oral mucosa must alert the cli...

Seven cases of malignant melanoma in the close relatives of children with osteosarcoma and chondrosarcoma are described. The association between certain childhood malignancies (adrenal cortical carcinoma, osteosarcoma, chondrosarcoma, retinoblastoma) and malignant melanoma is discussed and it is proposed that in certain families malignant melanoma may be another manifestation of the same gene d...