Glycation and lipid peroxidation are spontaneous reactions believed to contribute to the pathogenesis of nephrotic syndrome. Possible interrelations of glycated hemoglobin with reduced glutathione and malondialdehyde were evaluated in nephrotic syndrome patients. Eighteen nephrotic syndrome patients and 15 healthy controls were enrolled for this study. Glycated hemoglobin, reduced glutathione, ...

background : methamphetamine (ma) is an illegal amphetamine-like which stimulate the central nervous system. in recent years, ma has been widely abused worldwide. previous studies have suggested that oxidative stress (os) plays an important role in ma-induced toxicity. from this view, antioxidant therapy could be considered as a potential drug therapy in ma abusers. therefore, the objective of ...

background: cancer has the highest disease-related mortality rate in iran. reduced activity of paraoxonase reported in patients with cancer may be due to a reduction in its antioxidant properties and a subsequent increased risk of developing cancer. we aimed to assess antioxidant and oxidative status in patients with cancer through measuring the activity of pon1 as an antioxidant enzyme and det...

conclusions our results show that oxidative stress could play an important role in male infertility as well as in sperm motility and sperm morphology. patients and methods this case control study was conducted using 35 men with idiopathic infertility and 34 men with proven fertility. seminal plasma tac and mda were measured by ferric reducing ability of plasma (frap) and thiobarbituric acid (tb...

the present study investigated the effects of e. coli lipopolysaccharide (lps) induced mastitis model in rat on the activity of antioxidant enzyme systems. to achieve this purpose, e. coli lps were infused into the mammary gland of 12 rats 72 hr postpartum and compared with 12 rats in control group infused intramammary placebo sterile pyrogene – free, physiological saline. the antioxidant activ...

OBJECTIVES This study was undertaken to determine the effect of subacute exposure of peracetic acid on lipid peroxidation and hepatic enzymes in Wistar rats. METHODS 48 male animals in Treatment Group I, II and III received 0.2%, 2% and 20% peracetic acid daily for 2 and 4 weeks. RESULTS Serum malondialdehyde increased and Alanine Transaminase and Aspartate Transaminase decreased significan...

Oxygen free radicals play an important role in the pathogenesis of tissue damage in many pathological conditions, including liver diseases. The present study aims to investigate the possible relationship between serum malondialdehyde level, an index of lipid peroxidation, and ceruloplasmin level, a protective agent against lipid peroxidation, in chronic liver disease. A total of 65 consecutive ...

Introduction: Malondialdehyde (MDA) is a useful determinant to show high level of lipid peroxidation which lead to impaired cell function. Previous studies have mentioned there is a relationship between high oxidative stress and low anti-oxidant activity in patients with oral lichen planus. The aim of this study was to evaluate serum level of Malondialdehyde as an indicator of oxidative stress ...

AIMS to assess oxidative stress in acute pancreatitis, its evolution over time and its relationship with the severity of the disease. METHODS during a two-year period, patients with acute pancreatitis with less than 24 hours of pain were evaluated. Serum was obtained the first, second and fourth day from admittance, if complications were detected, and after recovery. Malondialdehyde was deter...

background and aims: flavonoids as polyphenolic naturally occurring compounds have antioxidant activity. there is increasing evidence suggests that flavonoids may affect the activity of enzymes. paraoxonase 1 is calcium - dependent enzyme that is present in high density lipoproteins. this enzyme has an important role in the prevention of low density lipoprotein oxidation. we investigated the ef...