Morphological study of rats kidneys after the simulation of rhabdomyolytic acute kidney injury by the single injection of 50% glycerol revealed the morphological changes in the renal cortex and medulla, which were manifested by the luminal obstruction of the cortical and medullary tubules with myoglobin casts, epithelial dystrophy and signs of coagulative necrosis. Use of glutathione improved t...

Drug-induced nephrotoxicity (DIN) accounts for up to 60% of hospital acquired acute kidney injury with considerable morbidity and mortality. Several efforts have been made to reduce drug-induced nephrotoxicity; however, DIN remains a matter of concern. Statins with their antioxidant, anti-inflammatory and anti-apoptotic effects may have the potential to protect kidney against DIN. The present r...

Green tea and hibiscus are widely consumed as traditional beverages in Yemen and some regional countries. They are relatively cheap and the belief is that they improve health state and cure many diseases. The aim of this study was to evaluate the potential protective and antibacterial activity of these two famous plants in vitro through measuring their antibacterial activity and in vivo through...

Background and Aim: Tessaria integrifolia Ruiz Pav. (also known as “Pájaro bobo”) is for its medicinal properties, including antiulcer, antiasthmatic, leishmanicidal, antipyretic, antispasmodic, diuretic, anti-inflammatory, analgesic, hepatoprotective effects. Therefore, we aimed to evaluate nephroprotective effects using a rat model of diclofenac-induced toxicity. Materials Methods: We adminis...

7 ABSTRACT: The antioxidant properties of methanolic extracts of six locally consumed plants in Nigeria were comparatively evaluated both in vitro and in vivo. The plants included V. amygdalina (bitter leaf); C. rubens (‘ebolo’); A. hybridus (‘tete’); J. tanjorensis (jatropha); G. africana (‘okazi’) and T. triangulare (water leaf). The in vitro study indicate that the DPPH radical scavenging ac...

Acute kidney injury (AKI) is a common clinical problem that still lacks effective treatment. Phosphodiesterase-5 (PDE5) inhibitors possess anti-apoptotic and anti-oxidant properties, making it a promising therapy for ischemia-reperfusion (I/R) injury of various organs. The present study evaluated the early nephroprotective effects of Tadalafil, a PDE5 inhibitor, in an experimental model of rena...

Background: World-renowned as primary healthcare, traditional medicine often represents the only therapeutic resource for many communities with very low incomes, although it shows valuable benefits. The objective of this investigation was to evaluate medicinal plants used treat infertility in Nyong & So’o Division (Cameroon) and effect Mammea africana, most commonly plant extract, on reprod...

BACKGROUND/AIMS Leaves of Echinodorus macrophyllus (EM), from the Alismataceae family, have been used in Brazilian folk medicine for their anti-inflammatory and diuretic properties. In this work, the diuretic and nephroprotective activities of crude extracts of EM were evaluated. METHODS Normal Wistar rats were given 0.9% NaCl containing either EM (10-300 mg/kg), furosemide (13 mg/kg) or argi...

renal ischemia-reperfusion (ir) injury is a common problem in kidney transplantation. there is increasing evidence about the role of the reactive oxygen species (ros) in these injuries and endogenous antioxidants seem to have an important role in decreasing the renal tissue injury. the aim of this study was to investigate the effects of kidney ir on renal antioxidant enzymes activity such as ca...