Objective(s): Because of the high total phenolic contents of Feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice.   Materials and Methods: Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP)...

BACKGROUND Wilms' tumor 1 (WT1) is a biological marker for predicting leukemia progression. In this study, mammea E/BB, an active compound from Saraphi (Mammea siamensis) seed extract was examined for its effect on down-regulatory mechanism of WT1 gene expression, WT1 protein and mRNA stability, and cell proliferation in K562 cell line. METHODS M. siamensis seeds were obtained from the region...

Medicinal plants may serve as a vital source of potentially useful new compounds for the development of effective therapy to combat a variety of kidney problems. Many herbs have been proven to be effectual as nephroprotective agents while many more are claimed to be nephroprotective but there is lack of any such scientific evidence to support such claims. Developing a satisfactory herbal therap...

Spironolactone Attenuates Oxidative Stress in Patients With Chronic Kidney Disease To the Editor: In one of the latest issues of Hypertension, Michea et al1 reported that the mineralocorticoid receptor antagonist spironolactone attenuates cardiac hypertrophy and oxidative stress of the heart in uremic rats. The results of our recent clinical study indicate that spironolactone acts to decrease t...

Syzygium polyanthum is traditionally used as anti-hypertensive. However, the nephroprotective effects of S. against hypertensive induced chronic kidney disease remains to be done. This study was conducted determine antioxidant properties and aqueous extract (AESP) in spontaneous rat model (SHR). The phytochemical constituent identified using screening HPLC methods. vitro activities were determi...

objective(s):to evaluate the effect of graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats. materials and methods: animals were grouped into 6: group 1 received gum acacia, group 2 received g. pictum ethanol extract (300 mg/kg), group 3 received gentamicin, groups 4, 5, 6 received gentamicin along with g. pictum at...

Phytochemical study of the aerial parts of Ficus palmata utilizing liquid-liquid fractionation and different chromatographic techniques resulted in the isolation of a new isomer of psoralenoside namely, trans-psoralenoside (5) in addition to, one triterpene: germanicol acetate (1), two furanocoumarins: psoralene (2), bergapten (3), one aromatic acid vanillic acid (4) and the flavone glycoside r...

Orthosiphon stamineus is the one of the important medicinal plant which used for kidney based problems traditionally. In the present investigation the ethanolic extracts of O. stamineus leaves have been used for the nephroprotective activity. The ethylene glycol used to inducing the urolithiasis in albino rats. The rats are divided into four groups namely I (Normal), II (Ethylene glycol induced...

Mushrooms represent a major and untapped source of potent new pharmaceutical products. The antioxidant, antiinflammatory, antinociceptive, antimutagenic, anticarcinogenic, antitumour, hepatoprotective, nephroprotective and cardioprotective activities of the methanolic extract of Ganoderma lucidum (Fr.) P. Karst. collected from tropical South India were evaluated for the revalidation of its util...

Protective effect of Camellia Sinensis L. leaf extract on lead acetate Induced nephrotoxicity in albino wistar rats were investigated by analyzing various biochemical parameters. Lead acetate induced kidney damage was well manifested by significant increase in renal parameters like urea, uric acid creatinine and serum electrolytes sodium, potassium,chloride, calcium, phosphorous and TBARS and d...