This research aims at studying the nephroprotective properties of BNO 2103 in a model chromate-induced renal failure rats and proving possibility using clinical practice for complex treatment chronic kidney disease (CKD). Materials methods. Fifty divided into five groups were studied. The drugs 2103, Prednisolone Lespephril administered within 20 days. excretory function functional state kidney...

Ischemia/reperfusion injury (I/R) is commonly related to acute kidney (AKI) and oxidative stress. Antioxidant agents are used treat this condition. Lippia sidoides a brazillian shrub with anti-inflammatory anti-oxidative properties. Thus, the aim of study evaluate effect ethanolic extract (LSEE) on in vivo vitro models AKI induced by I/R. Male Wistar rats were submitted unilateral nephrectomy i...

In ethnomedicine, the leaf of S. anomalum is used to treat a variety illnesses, including diabetes. The goal this study was assess effects extract and fractions on kidney function indices, renal histology, indicators oxidative stress in rats with diabetes caused by alloxan. Antioxidative renoprotective potentials (70-210 mg/kg) (140 were assessed determining markers levels, parameters histopath...

Chronic kidney disease (CKD) is a global problem all over the world. Special attention is paid to the action of natural compounds. This research was aimed to investigate the effect of complex phytochemical preparation (Herba centaurii, Radix levistici and Folia rosmarini) on dynamics of morphological changes in kidney tissue in animals with glomerulonephritis. We found a positive dynamics in th...

Calophyllum brasiliense (Calophyllaceae) is a tropical rain forest tree, mainly distributed in South and Central America. It is an important source of bioactive natural products like, for instance soulatrolide, and mammea type coumarins. Soulatrolide is a tetracyclic dipyranocoumarins and a potent inhibitor of HIV-1 reverse transcriptase and Mycobacterium tuberculosis. Mammea A/BA and A/BB coum...

Chronic kidney disease (CKD) is a major public health problem worldwide. Rhubarb has been shown to have nephroprotective and anti-fibrotic activities in patients with CKD. However, bioactive fractions and biochemical mechanism of anti-fibrotic properties of rhubarb remain unclear. Here we applied ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry together with u...

OBJECTIVE To investigate the antioxidant, antimicrobial, antiplasmodial, acute toxicity and haemolytic activities of methanolic extracts of three plants. Phytochemical analysis to determine the phenolic contents was also carried out. METHODS The 2,2-diphenyl-1-picryl-hydrazyl (DPPH) free radical scavenging, NCCLS broth microdilution and Plasmodium Lactate Dehydrogenase (pLDH) assays were used...

BACKGROUND Oxidative stress has been implicated in the progression of various diseases, which may result in the depletion of endogenous antioxidants. Exogenous supplementation with antioxidants could result in increased protection against oxidative stress. As concerns have been raised regarding synthetic antioxidant usage, the identification of alternative treatments is justified. The aim of th...

Abstract Background and Aims The most common effect of renal disease in the world is diabetic nephropathy (DN). Dipeptidyl peptidase–IV (DPP-IV) enzyme abundant present kidney, which increased nephropathy. A novel approach to treat type 2 diabetes mellitus (T2DM) along with DN, based on incretin hormones: glucagon-like peptide-1 (GLP-1) regulated by DPP-IV. We hypothesized that DPP-IV inhibitor...