Deltamethrin is -cyano pyrethroid insecticide used extensively in pest control. Although initially thought to be least toxic, a number of recent reports showed its toxicity in mammalian and non-mammalian laboratory and wildlife animal species. Lycopene is the pigment that gives tomatoes their red color and is one of four main carotenoids normally found in human blood and tissue. The present stu...

Calophyllum brasiliense (Clusiaceae) is a tree that grows mainly in the Atlantic Forest in Brazil. Its leaves possess antibacterial activity, cytotoxic activity against certain tumor cell lines, and antimicrobial activity in BALB/c mice infected with Leishmania (Leishmania) amazonensis.Aiming to identify ultrastructural changes and DNA fragmentation in Leishmania (Viannia) braziliensis, promast...

Telomere shortening has been implicated in the aging process and various age-associated disorders, including renal disease. Moreover, oxidative stress has been identified as an initiator of accelerated telomere shortening. We have shown previously that maternal protein restriction during lactation leads to reduced renal telomere shortening, reduced albuminuria, and increased longevity in rats. ...

Background: Trevo is a nutritional supplement with numerous bioactive natural products, with detoxifying and antioxidant properties. The purpose of this study was to investigate the ability of Trévo to protect against oxidative stress induced by lead in the kidneys of male Wistar rats.  Methods: Thirty-five healthy male Wistar rats were divided into five groups of seven rats each, using a rand...

Incretin-based therapies represent one of the most promising options in type 2 diabetes treatment owing to their good effectiveness with low risk of hypoglycemia and no weight gain. Other numerous potential beneficial effects of incretin-based therapies have been suggested based mostly on experimental and small clinical studies including its beta-cell- and vasculo-protective actions. One of the...

Polyalthia longifolia (Sonn.) Thwaites is a traditional medicinal plant with diverse properties including kidney protection. The present investigation was aimed to assess the phytochemical content, antioxidant activity and evaluate nephroprotective of (PL) 70% ethanolic leaf extract against cisplatin gentamicin-induced toxicity on HEK293 cell line. Phytochemical analysis confirmed presence flav...

Kidneys are the organs that have numerous biological roles. Their primary role is to maintain the homeostatic balance of body fluids by filtering and secreting metabolites (such as urea) and minerals from the blood and excreting the nitrogenous wastes along with water, as urine. Because the kidneys are poised to sense plasma concentrations of ions such as sodium, potassium, hydrogen, and compou...

Nine compounds have been isolated for the first time from Celtis africana, namely trans-N-coumaroyltyramine (1), trans-N-feruloyltyramine (2), trans-N-caffeoyltyramine (3), lauric acid (4), oleic acid (5), palmitic acid (6), lupeol (7), β-sitosterol (8) and oleanolic acid (9), respectively. Their structures have been elucidated by different spectroscopic techniques. The isolated compounds were ...

Received: Revised: Accepted: November 13, 2014 February 12, 2015 February 21, 2015 Gentamicin-induced nephrotoxicity is associated with free radicals generation in kidney tissue. Medicinal plants contain bioactive constituents that act as natural antioxidants, which can protect the biological system from oxidative stress. In this study, phytochemical constituents of aqueous extract of Calotropi...