The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), tovopyrifoli...

The present study involves the optimization of different solvent extract and Standardization of α-mangostin from fruit hulls of Garcinia mangostana was studied by gradient reverse-phase high-performance liquid chromatographic (HPLC) method for quality control and quantity determination. Chromatographic separation was carried out on Develosil RP C-18 (5 μm, 4.6 x 150mm) at room temperature using...

The present study is an attempt to evaluate the standardization of crude mangosteen and γ – mangostin from Garcinia mangostana on MCF-7 (breast cancer cell line) and Hep2 (laryngeal cancer cell line). The study includes cell doubling time, ED50 analysis (growth inhibition), cell proliferation assay and assessment of cell cytotoxicity by dye exclusion assay. The result of the study showed that t...

We investigated the effect of -mangostin purified from the fruit hull of the medicinal plant Garcinia mangostana on spontaneous prostaglandin E2 (PGE2) release and inducible cyclooxygenase 2 (COX-2) gene expression in C6 rat glioma cells. An 18-h treatment with -mangostin potently inhibited spontaneous PGE2 release in a concentration-dependent manner with the IC50 value of approximately 2 M, wi...

Environmental factors, such as soil height, plant age, conditions, maintenance, and seeds influence the content of secondary metabolites in an organism. The growing conditions can also affect active compounds plants. Xanthone is compound Garcinia mangostana Linn. One its derivatives α-mangostin, which has antioxidant, anticancer, antituberculosis antihistamine effects. This study aimed to deter...

Ekstrak kulit manggis (Garcinia mangostana L.) mengandung xanthone dengan senyawa utama alfa mangostin dan gamma-mangostin yang berfungsi sebagai antioksidan dalam melindungi mukosa lambung. Tujuan dari penelitian ini ingin mengetahui pengaruh pemberian ekstrak pelindung lambung tikus diinduksi asam asetilsalisilat (ASA). Penelitian menggunakan 24 ekor dibagi menjadi empat kelompok perlakuan te...

Virgin coconut oil (VCO) was used as co-extractant with supercritical carbon dioxide (scCO2) extraction for obtaining xanthones from mangosteen pericarp (MP) without organic co-solvents. In each experiment, 120 g of dried MP that had median particle sizes 0.85 mm used. Extraction 40% VCO using scCO2 (1.08 kg/h) 420 min at 430 bar and 70 °C gave α-mangostin (32.2 mg/g), γ-mangostin (7.2 (28.2 mg...

The TRPV3 calcium ion channel is vital for maintaining skin health and has been associated with various skin-related disorders. Since involved in the development of inflammation, inhibiting could be a potential treatment strategy. Alpha-mangostin isolated from Garcinia mangostana L. extract exhibits diverse positive effects on health; however, underlying mechanisms remain obscure. This study in...

SARS CoV-2 infection causes various clinical manifestations ranging from mild to severe. Acute RespiratoryDistress Syndrome (ARDS) is a severe complication of COVID-19 caused by activation the kallikreinkininsystem which produces bradykinin potent proinflammatory mediator. This research anin silico study aims determine potential active medicinal plant compounds in inhibiting thekallikrein-kinin...