Electrospray tandem mass spectrometry was applied to detect a series of inherited metabolic disorders during a newborn-screening pilot study and a selective screening in Japan. In our mass screening of 102,200 newborns, five patients with propionic acidemia, two with methylmalonic acidemia, two with medium-chain acyl-CoA dehydrogenase deficiency, three with citrullinemia type II, and one with p...

BACKGROUND Because the mortality rate from lung cancer is increasing sharply in Japan, lung cancer screening is being performed actively to assure early diagnosis and early treatment. However, its effectiveness is not clear, because it is extremely difficult to diagnose early microcarcinoma of the lungs (< 1 cm in greatest dimension) with the indirect X-rays that are used in mass screening. The...

background and objective: stop-bang questionnaire is a well-known obstructive sleep apnea (osa) screening tool. this study aimed to evaluate that patients with high probability of osa in stop-bang questionnaire meet the criteria for assessment by split-night polysomnography (psg). materials and methods: patients who were admitted to three sleep clinics and underwent full-night psg entered into ...

BACKGROUND Cardiovascular primary prevention should be targeted at those with the highest global risk. However, it is unclear how best to identify such individuals from the general population. The aim of this study was to compare mass and targeted screening strategies in terms of effectiveness, cost effectiveness and coverage. METHODS The Scottish Health Survey provided cross-sectional data o...