BACKGROUND Preterm labor is the leading cause of infant morbidity and mortality so it may be necessary to administer tocolytics for treatment of it. OBJECTIVE The aim of this study was to compare the efficacy and safety of magnesium sulfate and nifedipine in the management of preterm labor. MATERIALS AND METHODS 100 women with documented preterm labor were randomly assigned to receive magne...

Health-care-associated infections in developing countries are a serious issue that is scarcely addressed in the scientifi c literature. Hence, the systematic review and meta-analysis in The Lancet by Benedetta Allegranzi and colleagues from WHO, which assessed the epidemiology of health-care-associated infections, is impressive. In this study, the investigators analysed pooled data from 220 sel...

OBJECTIVES To review the standard of care in cases of maternal mortality due to hypertensive diseases in pregnancy and to make recommendations for its improvement. DESIGN Care given to women with hypertensive disease in pregnancy was audited and substandard care factors identified. SETTING Confidential enquiry by the Dutch Maternal Mortality Committee (MMC) from the Netherlands Society of O...

The A3243G mutation within the human mitochondrial (hs mt) tRNALeuUUR gene is associated with maternally inherited deafness and diabetes (MIDD) and other mitochondrial encephalopathies. One of the most pronounced structural effects of this mutation is the disruption of the native structure through stabilization of a high-affinity dimeric complex. We conducted a series of studies that address th...

BACKGROUND Magnesium sulfate (MgSO4) is the most effective seizure prophylaxis in the management of severe pre-eclampsia, and its use is progressively spreading in our environment. It was introduced at the pioneer teaching hospital of southeastern Nigeria in 2007. A study on the outcome of its use is therefore necessary. OBJECTIVES The objective was to determine the effect of introducing MgSO...

at present, many drugs are used for inhibition of uterine contractions, but the proportions of preterm labors are increasing. although magnesium sulfate is the most commonly prescribed parenteral tocolytic agent, but it’s optimal use has yet to be delineated. in this study a high-dose protocol for magnesium sulfate tocolytic therapy was compared with a low-dose regimen. one hundred patients adm...

BACKGROUND Trace elements and specially minerals are critical for the development of fetus. Many minerals are transferred to the fetus for fetal stores in the latter part of the pregnancy. It has been shown that various trace elements such as Zinc, Iron, Calcium and Magnesium are metabolically interrelated and there is alteration in their concentration during pregnancy. Beyond pregnancy is asso...

BACKGROUND Magnesium sulphate is extensively used in obstetrics for the treatment and prevention of eclampsia. A recent meta-analysis has shown that magnesium sulphate is an effective fetal neuroprotective agent when given antenatally to women at risk of very preterm birth. Term infants account for more than half of all cases of cerebral palsy, and the incidence has remained fairly constant. It...

BACKGROUND Preeclampsia is a pregnancy multisystem disorder of unknown etiology. It is a significant cause of maternal and fetal morbidity and mortality. OBJECTIVES Due to the significant role of magnesium in physiological regulation of blood pressure, this study was conducted to measure the level of magnesium in pre-eclampsia and control groups since the beginning of the pregnancy. MATERIA...

at the present, many drugs are used for inhibition of uterine contractions, but the proportions of preterm labors are increasing. although magnesium sulfate is the most commonly prescribed parenteral tocolytic agent, but its optimal use has yet to be delineated. in this study a high-dose protocol for magnesium sulfate tocolytic therapy was compared with a low-dose regimen. one-hundred patients ...