Abstract AIMS To succeed in clinical trials for glioblastoma we need vitro models capable of more faithfully replicating dis- ease biology and accurately predicting patient drug responses. this end, new bioprinting technologies have the potential to biofabricate clinically relevant biomimetic tissues which can accelerate discovery additionally serve as a platform personalized medicine. METHOD W...

D. S. Grant1,*, J. L. Kinsella2, M. C. Kibbey1, S. LaFlamme1, P. D. Burbelo1, A. L. Goldstein2 and H. K. Kleinman1 1Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bldg 30, Rm 430, Bethesda, MD 20892, USA 2Laboratory of Cardiovascular Science, Gerontology Reseach Center, NIA, Baltimore, MD, USA 3Department of Biochemistry and Molecular ...

Most forms of tissue healing depend critically on revascularisation. In soft tissues and in vitro, mechanical stimuli have been shown to promote vessel-forming activity. However, in bone defects, increased interfragmentary motion impairs vascular regeneration. Because these effects seem contradictory, we aimed to determine whether a range of mechanical stimuli exists in which angiogenesis is fa...