The objective of the present study was to investigate the use of propranolol-magnesium aluminium silicate intercalated complexes as drug reservoirs in hydroxypropylmethylcellulose tablets. The matrix tablets containing the complexes were prepared and characterised with respect to propranolol release and were subsequently compared with those loading propranolol or a propranolol-magnesium alumini...

Monolithic matrix tablets of ambroxol hydrochloride were formulated as sustained release tablets employing hydroxypropyl methylcellulose polymer, and the sustained release behaviour of the fabricated tablets was investigated. Sustained release matrix tablets containing 75 mg ambroxol hydrochloride were developed using different drug polymer ratios of hydroxypropyl methylcellulose. Tablets were ...

Objectives: Carvedilol (CVD) is a nonselective β-adrenergic blocker that suffers from low absolute bioavailability (25-35%) due to first-pass metabolism. CVD-loaded buccal tablets were developed as a promising approach to overcome this limitation. Methods: The bilayers tablets were prepared by the direct compression technique. CVD-containing layer was based on one of four high molecular weight ...

The aim of study is to develop colon targeted system for metronidazole using guar gum and xanthan gum. Matrix formulations containing various proportions of guar gum and xanthan gum were prepared by wet granulation technique. Later on, multilayer tablets were prepared by using 50 mg and 100 mg of guar gum as release controlling layer on either side of (M5) matrix tablets of metronidazole. The i...

When the Internet became more interactive it turned passive consumers of information into active providers of such. Over the time, volunteers built impressive databases filled with information for virtually every niche. In this paper we present RITE, an idea for augmenting films and TV serials with supplementary information that is freely available on the Internet. An easy, yet powerful interfa...

Glucocorticoids are drugs of choice for treatment of laryngotracheitis (croup). They may be administered orally as tablets or juice, locally as inhalation or rectally as suppository or capsule. If doctors decide to use a rectal administration for practical reasons, it is obvious from a pharmacokinetic and pharmacodynamic point of view that prednisolone capsules have an earlier and stronger anti...

The effect of three different types of polymer chain structures on the polymer release from hydrophilic matrix tablets was investigated by comparing a synthetic semi-crystalline linear polymer (PEO), a branched amorphous polysaccharide (dextran) and an amorphous substituted cellulose derivative (HPMC). The polymer release rates for tablets containing mixtures of high and low molecular weight gr...

The aim of the study was to develop and physicochemicaly characterize single unit controlled delivery system of Theophylline and was formulated as floating matrix tablet by direct compression method using gas generating agent (sodium bicarbonate) and various viscosity grades of hydrophilic polymers (HPMC K15M, K4M; HPC and Carbapol 934P). Formulation was optimized on the basis of buoyancy and i...

Capsules are used for filling different materials like Powders, Granules, Beads, Tablets, Capsules, Pastes etc.. Some of the disadvantages associated with conventional capsule: They are easily tampered with (although techniques exist for preventing this). They are subject to the effects of relative humidity and to microbial contamination. Some of the innovations are targeted to:  Overcome the ...

The thermodynamical conditions and the neutron density produced in a laser-induced implosion of deuterium-tritium (DT) filled capsule at National Ignition Facility (NIF) are closest laboratory analog stellar conditions. We plan to investigate neutron-induced reactions on 40 Ar, namely Ar( n , 2 ) 39 t 1/2 =268 y), γ) 41 Ar(110 min) potential rapid two-neutron capture reaction Ar(2 42 Ar(33 y) a...