PURPOSE: The objective of the present study is to develop colon targeted drug delivery systems for sennosides using guar gum as a carrier. METHODS: Matrix tablets containing various proportions of guar gum were prepared by wet granulation technique using starch paste as a binder. The tablets were evaluated for content uniformity and in vitro drug release study as per BP method. T50 % value from...

Abstract Chemical mapping by Raman spectroscopy is widely used in the pharmaceutical industry to characterise distribution of components within tablets; however, current methods do not go beyond examining an exposed surface area a sample. There are known limitations with estimating domain size and shape statistics from 2D chemical images as values obtained will depend on where sectioned, potent...

In this study Fusion Deposition Modelling (FDM) was employed to design and fabricate a bilayer tablet consisting of isoniazid (INZ) rifampicin (RFC) for the treatment tuberculosis. INZ formulated in hydroxypropyl cellulose (HPC) matrix allow drug release stomach (acidic conditions) RFC hypromellose acetate succinate (HPMC – AS) upper intestine (alkaline conditions). This may offer better clinic...