Awareness of the release kinetics active drugs is important in formulating that have desired delivery and predicting behaviour formulated drug vivo. The study aims to determine mechanism from griseofulvin tablets with different surfactants using mathematical models compare use graphs DD solver software fitting dissolution profiles kinetic models. batches P1 -P3 were composed surfactant - PEG 40...

The dissolution characteristics of melt granulations of paracetamol in capsule and tablet dosage form were compared to determine whether the dissolution characteristics of the granules can be actualized by formulating them as rapidly disintegrating tablets. The term melt granulation refers here to the wax-matrix granules that were formed by triturating the drug powder (paracetamol) with a melte...

The aim of this study was to develop new multi-layer matrix tablets to achieve bimodal drug release profiles (fast release/slow release/fast release). Hydroxypropyl methylcellulose acetate succinate (HPMCAS, type MF) was chosen as a matrix former, because it is water-insoluble at low, and water-soluble at high pH values. Studies focused on the elucidation of the drug release mechanisms from HPM...

In this study, the attitudes, expectations and views of 206 students in four high schools within the scope of the FAT_ IH project in Turkey were assessed regarding tablet PC technology after six months of a pilot plan that included the distribution of tablet PCs to students. The research questions of this study are whether there is a meaningful difference between tablet PC use by male and femal...

Multi-Unit Particulates (MUPs) with matrix pellets are used to develop controlled release products of various active pharmaceutical ingredients. They may allow improvement in solubility and thereby bioavailability poorly soluble drugs. Omeprazole magnesium is a derivative benzimidazole which belongs the group proton pump inhibitors that exhibits degradation gastric acid short biological life va...

Purpose: Triple solid dispersion adsorbates (TSDads) and spherical agglomerates (SA) present new techniques that extensively enhance dissolution of poorly soluble drugs. The aim of the present study is to hasten the onset of hypoglycemic effect of glimepiride through enhancing its rate of release from tablet formulation prepared from either technique. Methods: Drug release from TSDads or SA tab...

Conventional dry-coating method can cause problems like non-core, double-core, off-center, inlay, and cooking, caused by the core tablet supply system. Hence, dry coating is not as widely used as normal tablets. One-step dry-coating (OSDrC) technology is an innovative one to solve these problems. OSDrC technology, which does not require a separate manufacturing process for the core, can even us...