Dissolution stability over the entire shelf life duration is of critical importance to ensure the quality of solid dosage forms. Changes in the drug release profile during storage may affect the bioavailability of drug products. This study investigated the stability of a commercial tablet (Lescolr XL) when stored under accelerated conditions (40 oC/75% r.h.). Terahertz pulsed imaging (TPI) was ...

The characteristics of a new Polyvinylacetate/Povidone based excipient, Kollidon® SR were evaluated for application in extended release matrix tablets. The effects of the following formulation and process variables on tablet properties and drug release were tested: Kollidon® SR concentration in the tablet, addition of external binder for wet granulation, presence of an enteric polymer in the ma...

Background and purpose of study: In the present investigation, an attempt was made to increase therapeutic effectiveness, reduce dose frequency and improvement in patient compliance, by developing sustained release matrix tablets of Diclofenac sodium using tamarind gum as release modifier. Methods: Six batches of sustained release matrix tablets of Diclofenac sodium were prepared by using diffe...

Prediction using pure standards is expected to be biased whenever the slope of the calibration is affected by the presence of sample matrix. Moreover, in the presence of unknown spectral interferents, first-order algorithms like partial least squares cannot be used. In this study, a method for determination of carvedilol (CAR) in tablet and urine samples is proposed by excitation-emission fluor...

megaloporous controlled release tablets of diclofenac sodium (ds) were prepared with two kinds of granules. one of them is the restraining-phase matrix granule (rmg) and it controls the release rate of the drug. the other one is the soluble housing-phase matrix granule (hmg) and controls liquid penetration into the system. carnauba wax and eudragit l 100 polymers were used to constitute the res...